杞菊地黄丸联合氯沙坦钾片治疗更年期失眠伴高血压病临床研究
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R256.23

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Clinical Study of Qiju Dihuang Pills Combined with Losartan Potassium Tablets for Menopause Insomnia with Hypertension
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    摘要:

    目的:观察杞菊地黄丸联合氯沙坦钾片治疗更年期失眠伴高血压病的疗效。方法:选取116例罹患失眠症且合并高血压病、辨证属肾阴亏虚证的更年期女性患者,随机分为对照组与观察组各58例,对照组服用氯沙坦钾片与艾司唑仑片治疗,观察组服用杞菊地黄丸与氯沙坦钾片治疗,2组均连续治疗4周。观察2组患者治疗后的效果,与匹兹堡睡眠质量指数量表(PSQI)评分、血压的变化及治疗过程中出现的不良反应情况。结果:治疗后,观察组总有效率94.8%,对照组总有效率75.9%,2组比较,差异有统计学意义(P<0.05)。2组PSQI睡眠时间、入睡时间、睡眠障碍、睡眠效率、日间功能评分均较治疗前下降(P<0.05),观察组各指标评分均低于对照组(P<0.05)。2组舒张压、收缩压均较治疗前改善(P<0.05);观察组舒张压、收缩压值均低于对照组(P<0.05)。结论:采用杞菊地黄丸联合氯沙坦钾片治疗肾阴亏虚型更年期失眠伴高血压病患者,可使患者的睡眠状态与血压均得到显著改善,疗效优于氯沙坦钾联合艾司唑仑治疗。

    Abstract:

    Objective: To observe the clinical effect of Qiju Dihuang pills combined with losartan potassium tablets for menopause insomnia with hypertension.Methods:Selected 116 cases of menopause female patients suffering from insomnia with hypertension and syndromes of kidney yin deficiency,and divided them into the control group and the observation group randomly,58 cases in each group.The control group took losartan potassium tablets and estazolam tablets for treatment,while the observation group took Qiju Dihuang pills and losartan potassium tablets for treatment.Both groups continuously receivedthe treatment for 4 weeks.Observed the clinical effect of patients in both groups after treatment,pittsburgh sleep quality index(PSQI)scores,and changes of blood pressure as well as adverse reaction in the treatment.Results:After treatment,the total effective rate was 94.8%in the observation group and 75.9%in the control group,the difference being significant(P < 0.05).PSQI scores in the sleep time,time for falling asleep,sleep disorders,sleep efficiency,and daytime function of both groups were all lower than those before treatment(P<0.05).Each index in the observation group was lower than that in the control group(P<0.05).Diastolic blood pressure and systolic pressure of two groups were both improved when comparing with those before treatment(P < 0.05);diastolic blood pressure and systolic pressure of the observation group were both lower than those of the control group(P<0.05).Conclusion:The application of Qiju Dihuang pills combined with losartan potassium tablets for patients of menopause insomnia with hypertension and kidney yin deficiency syndrome can improve sleep and blood pressure of patients,and its curative effect is better than that with losartan potassium combined with estazolam.

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厉钗微,谷雪梅.杞菊地黄丸联合氯沙坦钾片治疗更年期失眠伴高血压病临床研究[J].新中医,2018,50(3):61-63

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  • 在线发布日期: 2018-03-04
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