To observe the clinical effect of Shenqi Erzhi tang combined with western medicine for IgA nephropathy(IgAN)of qi-yin deficiency type.Methods：Divided 60 cases of patients with IgAN of qi-yin deficiency type into the treatment group and the control group randomly，30 cases in each group.The control group was given routine western medicine for treatment，while the treatment group was additionally given modified Shenqi Erzhi tang for treatment.Observed quantitative urinary protein in 24 hours， serum creatinine(SCr)， urine red blood cell count， and the changes of Chinese medicine syndrome scores of patients and evaluated the clinical effect.ResultsAfter one month of treatment，compared the levels of SCr in two groups and the quantitative urinary protein in 24 hours and urine red blood cell count in the control group with those before treatment，there were no significant differences being found(P ＞ 0.05)；the quantitative urinary protein in 24 hours and urine red blood cell count in the treatment group were decreased when compared with those before treatment and were lower than those in the control group at the same period(P ＜ 0.05).After two months of treatment，the quantitative urinary protein in 24 hours，urine red blood cell count，and levels of SCr in both groups were all decreased when compared with those before treatment；the quantitative urinary protein in 24 hours and urine red blood cell count in the treatment group were lower than those in the control group(P＜0.05).There was no significant difference being found in the comparison of levels of SCr between two groups(P ＞ 0.05).At the end of 1stand 2ndmonth of treatment，Chinese medicine syndrome scores of two groups were all decreased when compared with those before treatment(P ＜ 0.05)；Chinese medicine syndrome scores in the treatment group were lower than those in the control group at the same period(P＜0.05).The total effective rate was 93.3%in the treatment group and 66.7%in the control group，difference being significant(P＜ 0.01).Conclusion：The therapy of modified Shenqi Erzhi tang combined with western medicine for IgAN of qi-yin deficiency type has a significant clinical effect and can reduce the quantitative urinary protein in 24 hours，urine red blood cell count and levels of SCr more effectivly when compared with the therapy of routine western medicine thus to improve the clinical symptoms of patients and to delay the progress of this disease.