Objective：To observe the clinical effect of Fufang Shangtong capsules combined with posterior internal fixation for thoracolumbar fracture and its effect on fibrinogen(FIB)， nerve function and serum inflammatory factors.Methods：Divided 116 cases of patients with posterior internal fixation into two groups randomly according to random number table，58 cases in each group.Based on treatment of health education and diet guidance in two groups，the control group receivedposterior internal fixation for treatment，while the observation group received posterior internal fixation combined with Fufang Shangtong capsules.Observed Chinese medicine syndrome scores，pain degree，activity of daily living，nerve function as well as clinical effect，and detected FIB，tumor necrosis factor-α(TNF-α)，interleukin-2(IL-2)and interleukin-6(IL-6)in both groups.Results：After treatment，scores of Chinese medicine syndrome， visual analogue scales(VAS)and National Institutes of Health stroke scale(NIHSS)as well as levels of blood FIB，TNF-α，IL-2 and IL-6 in both groups were lower than those before treatment，while ADL scores were higher than those before treatment，differences being significant(P ＜0.05，P ＜ 0.01).The respective comparisons of scores of Chinese medicine syndrome，VAS，NIHSS and ADL as well as levels of blood FIB，TNF-α，IL-2 and IL-6 between the two groups showed significance in differences(P＜0.05，P＜0.01).The total effective rate was 94.83%in the observation group，remarkably higher than that in the control group which was 82.76%，the difference being significant(P＜0.05).Conclusion：The therapy of Fufang Shangtong capsules combined with posterior internal fixation can effectively improve nerve function and activity of daily living of patients with thoracolumbar fracture，and improves levels of blood FIB and serum inflammatory factors as well as improves clinical effect.