Objective： To observe the clinical effect of modified Danggui Sini tang combined with TDP for primary dysmenorrhoea with syndrome of stagnation and congelation of cold-damp.Methods：Selected 132 cases of patients with primary dysmenorrhoea with syndrome of stagnation and congelation of cold-damp，and divided them into the control group and the observation group randomly，66 cases in each group.The control group receivedIbuprofen sustained-release capsules for treatment，while the observation group received modified Danggui Sini tang combined with TDP for treatment.Observed the changes of Chinese medicine syndrome scores，menstrual status，indexes of uterine artery blood flow，monocyte chemoattractant protein-1(MCP-1)，high-mobility group box protein 1(HMGB1)，serum β-endorphin(β-EP)and prostaglandin E2(PGE2)in both groups before and after treatment.Results： After treatment， Chinese medicine syndrome scores in both groups were lower than those before treatment(P ＜ 0.05)；Chinese medicine syndrome scores in the observation group were lower than those in the control group(P ＜ 0.05).After treatment，incidence of menstruation with dark purple color and blood clots in both groups was lower than that before treatment(P ＜ 0.05)；incidence of menstruation with dark purple color and blood clots in the observation group was lower than that in the control group(P ＜ 0.05).PI，RI and A/B in uterine artery of the observation group after treatment were lower than those before treatment，and were all lower than those of the control group in the same period，differences being significant(P ＜ 0.05).Compared PI，RI and A/B in uterine artery of the control group after treatment with those before treatment，there were no significant differences being found(P ＞ 0.05).After treatment，levels of MCP-1 and HMGB1 in both groups were lower than those before treatment(P ＜ 0.05)，and levels of β-EP and PGE2were higher than those before treatment(P＜0.05).Levels of MCP-1 and HMGB1 in the observation group were lower than those in the control group(P ＜ 0.05)， and levels of β-EP and PGE2were higher than those in the control group(P＜0.05).Conclusion：Modified Danggui Sini tang combined with TDP has definite clinical effect in treating primary dysmenorrhoea with syndrome of stagnation and congelation of cold-damp，which can effectively improve the menstrual status and indexes of uterine artery blood flow of patients，and regulate the levels of cytokine such as MCP-1 and HMGB1.