当归四逆汤加减联合TDP治疗原发性痛经寒湿凝滞证临床观察
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R271.11+3

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Clinical Observation of Modified Danggui Sini Tang Combined with TDP for Primary Dysmenorrhoea with Syndrome of Stagnation and Congelation of Cold-damp
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    摘要:

    目的:观察当归四逆汤加减联合TDP治疗原发性痛经寒湿凝滞证的临床疗效。方法:选取132例原发性痛经寒湿凝滞证患者为研究对象,随机分为对照组和观察组各66例。对照组采用布洛芬缓释胶囊治疗,观察组采用当归四逆汤加减联合TDP治疗。观察2组治疗前后中医症状积分、月经情况、子宫动脉血流指标、单核细胞趋化蛋白-1(MCP-1)、高迁移率族蛋白1(HMCJBI)、血清β-内啡肽(β-EP)及前列腺素E2(PGE2)的变化。结果:治疗后,2组中医症状积分均较治疗前降低(P<观察组的中医症状积分低于对照组(P<0.05)。治疗后,2组月经颜色紫暗及月经有血块发生率均较治疗前降低(P<0.05);观察组月经颜色紫暗及月经有血块发生率均低于对照组(P<0.05)。观察组治疗后子宫动脉PI、RI及A/B均较治疗前降低,且均低于对照组同期,差异均有统计学意义(P<0.05),对照组治疗后子宫动脉PI、RI及A/B与治疗前比较,差异均无统计学意义(P>0.05)。治疗后,2组MCP-1及HMGB1水平均较治疗前降低(P<0.05),3-EP及PGE:水平均较治疗前上升(P<0.05);观察组MCP-1、HMGB1水平均低于对照纽(P<0.0习,(3-EP、PGE7水平均高于对照组(P<0.05)。结论:当归四逆汤加减联合TDP治疗原发性痛经寒湿凝滞证疗效确切,可有效改善患者的月经情况和子宫血流动力学指标,调节MCP-1、HMGB1等细胞因子水平。

    Abstract:

    Objective: To observe the clinical effect of modified Danggui Sini tang combined with TDP for primary dysmenorrhoea with syndrome of stagnation and congelation of cold-damp.Methods:Selected 132 cases of patients with primary dysmenorrhoea with syndrome of stagnation and congelation of cold-damp,and divided them into the control group and the observation group randomly,66 cases in each group.The control group receivedIbuprofen sustained-release capsules for treatment,while the observation group received modified Danggui Sini tang combined with TDP for treatment.Observed the changes of Chinese medicine syndrome scores,menstrual status,indexes of uterine artery blood flow,monocyte chemoattractant protein-1(MCP-1),high-mobility group box protein 1(HMGB1),serum β-endorphin(β-EP)and prostaglandin E2(PGE2)in both groups before and after treatment.Results: After treatment, Chinese medicine syndrome scores in both groups were lower than those before treatment(P < 0.05);Chinese medicine syndrome scores in the observation group were lower than those in the control group(P < 0.05).After treatment,incidence of menstruation with dark purple color and blood clots in both groups was lower than that before treatment(P < 0.05);incidence of menstruation with dark purple color and blood clots in the observation group was lower than that in the control group(P < 0.05).PI,RI and A/B in uterine artery of the observation group after treatment were lower than those before treatment,and were all lower than those of the control group in the same period,differences being significant(P < 0.05).Compared PI,RI and A/B in uterine artery of the control group after treatment with those before treatment,there were no significant differences being found(P > 0.05).After treatment,levels of MCP-1 and HMGB1 in both groups were lower than those before treatment(P < 0.05),and levels of β-EP and PGE2were higher than those before treatment(P<0.05).Levels of MCP-1 and HMGB1 in the observation group were lower than those in the control group(P < 0.05), and levels of β-EP and PGE2were higher than those in the control group(P<0.05).Conclusion:Modified Danggui Sini tang combined with TDP has definite clinical effect in treating primary dysmenorrhoea with syndrome of stagnation and congelation of cold-damp,which can effectively improve the menstrual status and indexes of uterine artery blood flow of patients,and regulate the levels of cytokine such as MCP-1 and HMGB1.

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郭瑞玲.当归四逆汤加减联合TDP治疗原发性痛经寒湿凝滞证临床观察[J].新中医,2018,50(3):131-134

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  • 在线发布日期: 2018-03-04
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