Objective： To explore the administration law of SHEN Minhe in treating liver cancer based on syndrome differentiation.Methods：Collected 89 cases of patients with liver cancer from Chinese medicine chief physician SHEN Minhe during January 1st， 2014 to December 31st， 2016， total clinical visits being 525.Clinical information of patients was established into a basic database of prescriptions.The flavor frequency，accumulative frequency of medicine，natures and tastes of medicine in prescriptions were analyzed by descriptive analysis，and 51 kinds of medicine in the highest frequency were analyzed by hierarchical cluster analysis.Results：The number of flavors ranged from 3 to 14 in each prescription，with an average of 10.097.Among 525 clinical visits of 89 cases of patients with liver cancer，275 kinds of medicines were used in total.The cumulative frequency of medicine was 5 244，in which the medicine with the highest frequency was poria，the most frequently used nature of medicine was"neutral"，while the most frequently appeared flavor of medicine was"sweet"，the most frequently used medicinal category was"tonifying medicine".These kinds of medicine were classified into 20 categories by cluster analysis，involving prescriptions such as Xiaochaihu tang，Liuwe Dihuang pills，Yinchenhao tang and Tianma Gouteng yin，as well as herb pairs like rhizoma coptidis and fructus evodiae，radix platycodonis and fructus aurantii，radix ophiopogonis and fructus lycii and so on.Conclusion：SHEN Minhe mainly uses treatment of tonifying and replenishing the liver and spleen for liver cancer based on syndrome differentiation，and supplements with treatments like clearing heat and detoxifying，promoting urination and percolating dampness，as well as dissolving phlegm and dissipating masses.SHEN Minhe is good at using classical formulas from the perspective of clinical prescriptions and medication，using medicine precisely and appropriately and focusing on primary symptoms directly.