Objective： To observe the clinical effect of Xiao'er Resuqing granules for influenza A with syndrome of wind-heat invading the wei-exterior in children.Methods：Divided 140 cases of children with influenza A with syndrome of wind-heat invading the wei-exterior into the control group and the observation group randomly，70 cases in each group.The control group was treated with oseltamivir granules along with symptomatic treatment including antipyretic analgesic，antiallergic，antitussive and other medicine.The observation group was additionally given Xiao'er Resuqing granules based on the treatment of the control group.Compared the clinical effect of the two groups and recorded the axillary temperature and antipyretic time at different time periods as well as symptom scores of syndrome of wind-heat invading the wei-exterior after treatment.Results：The total effective rate was 96.97%in the observation group，higher than that in the control group which was 84.62%，the difference being significant(P＜0.05).After treatment，the axillary temperature in both groups was decreased when compared with that before treatment and the axillary temperature after 24 h and 48 h of treatment in the observation group was lower than that in the control group(P ＜ 0.05).After 72 h of treatment，there was no significant difference being found in the comparison of axillary temperature(P＞0.05).The antipyretic time in the observation group was shorter than that in the control group，the difference being significant(P ＜ 0.05).After treatment，scores of fever，cough，stuffy or runny nose and sweating were all decreased when compared with those before treatment(P＜0.01).Scores of the above symptoms in the observation group were lower than those in the control group(P＜0.01).Conclusion：Based on the treatment of western medicine，the additional application of Xiao'er Resuqing granules for influenza A with syndrome of wind-heat invading the wei-exterior in children can effectively alleviate the clinical symptoms of children and reduce the fever rapidly，whose effect is superior to the simple western medicine treatment.