Objective：To observe the therapeutic effect of Yiqi Xiaogu tang and Lishui patch on patients with cirrhosis ascites caused by hepatitis B virus and explore its possible mechanism.Methods：Divided 68 cases of patients with cirrhosis ascites caused by hepatitis B virus into two groups randomly，34 cases in each group.The control group was given routine treatment，while the treatment group was additionally given oral administration of Yiqi Xiaogu tang and Lishui patch attached to the umbilicus based on the treatment of the control group.After eight weeks of treatment，compared the symptoms，signs，liver function，growth hormone(GH)in serum and insulin-like growth factor-1(IGF-1)before and after treatment in the two groups.Results：Compared the clinical effect in the two groups，the total effective rate was 94.12%in the treatment group and was 85.29%in the control group，the difference being significant(P＜0.05).After treatment，the respectivecomparison of weight loss and the reduction of abdominal circumference between the two groups showed significance in differences(P＜0.05，P＜0.01).The total urine volume within 24 hours in the treatment group was more than that in the control group，the difference being significant(P＜0.05).The average times of daily defecation in the treatment group was obviously increased when compared with that in the control group，the difference being significant(P＜0.05).The dosage of furosemide and spironolactone in the treatment group was obviously less than that in the control group，differences being significant(P＜0.05).There were more cases of albumin used in the control group than in the treatment group，the difference being significant(P＜0.05).When compared the dosage of albumin between the two groups，due to the heterogeneity of variance and the application of rank sum test of two independent samples，the difference was significant(P＜0.05).The comparisons ofliverfunction and indexes ofprothrombin activity as Alanine aminotransferase(ALT)，Aspartate aminotransferase(AST)， Albumin(Alb)， Total bilirubin(TBil)and prothrombin time activity(PTA)in the two groups showed significance in differences when respectively compared with those before treatment(P＜0.05).The A/G after treatment in the treatment group was compared with that before treatment，difference being significance(P＜0.05).After treatment， the comparisons of the ALT，AST，Alb，TBil，PTA and A/G between the two groups showed significance in differences(P＜0.05).After treatment，the GH in the treatment group was lower than that before treatment and was also lower than that in the control group after treatment，differences was significant(P＜0.05).The IGF-1 in the treatment group was higher than that before treatment and was also higher than that in the control group after treatment，differences was significantP＜ 0.05).Conclusion：The therapy of Yiqi Xiaogu tang and Lishui patch has good curative effect in treating patients with cirrhosis ascites caused by hepatitis B virus，which can relieve the clinical symptoms.The mechanism is possibly related to that the therapy stimulates the increase of IGF-1 so as to stimulate the synthesis of liver proteins and overcome the growth hormone resistance of cirrhosis.