Objective：To observe the clinical effect of the method of reinforcing qi，activating blood and strengthening the kidney for early diabetic nephropathy.Methods：Divided 150 cases of patients with early diabetic nephropathy into two groups randomly，the treatment group being 76 cases and the control group being 74 cases.The control group was given the routine treatment including the routine guidance of lifestyle，the treatment of lowering glucose，lipid and blood pressure and so on，while the treatment group additionally received Chinese herbal decoction of reinforcing qi，activating blood and strengthening the kidney orally.The course of treatment for both groups lasted for 3 months.Observe fasting blood glucose，glycosylated hemoglobin，blood lipid，renal function and the clinical effect.in the two groups.Results：The total effective rate was 81.6%in the treatment and 67.6%in the control group，difference being significant(P＜0.05).After treatment，there were significant differences being found(P＜0.05)，when comparing the serum blood glucose indexes including fasting blood glucose(FBG)and glycosylated hemoglobin(HbA1c)as well as the serum lipids indexes including cholesterol(TC)，triglyceride(TG)，high-density lipoprotein cholesterol(HDL-C)， low-density lipoprotein cholesterol(LDL-C)， serum creatinine(SCr)， blood urea nitrogen(BUN)，microalbuminuria(mAlb)，glomerular filtration rate(eGFR)and cystatin C(Cys-C)in the treatment group with those in the control group，and the treatment was better than the control group.Conclusion：The method of reinforcing qi，activating blood and strengthening the kidney for early diabetic nephropathy can not only lower the blood glucose and lipid，but also improve the renal function significantly.