Objective： To observe the clinical effect of Chaizao Longmu tang for patients with diabetic peripheral neuropathy with depressive state.Methods：Divided 60 cases of patients into two groups randomly，30 cases in each group.The observation group was given Chaizao Longmu tang orally for treatment，while the control group was given flupentixol and melitracen orally.The treatment lasted for 14 days in both groups.Compared the abnormal rate of 10 g Semmes-Weinstein monofilament examination(10 g SWME)，vibration perception thresholds(VPT)，total symptoms score(TSS)，visual analogue scale(VAS)，Hamilton depression rating scale(HAMD-17)and adverse reactions before and after treatment in the two groups.Results：After treatment，VPT，TSS，VAS and HAMD-17 in the two groups were improved when compared with those before treatment，differences being significant(P＜0.05).The abnormal rate of 10 g SWME，VPT，TSS，VAS and HAMD-17 in the observation group were improved more obviously than those in the control group，differences being significant(P＜0.05).Conclusion：The therapy of Chaizao Longmu tang for patients with diabetic peripheral neuropathy with depressive state in this study is safe and effective，which has obvious advantages when compared with routine treatment of modern medicine.