肾康颗粒治疗慢性尿酸性肾病临床研究
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R692

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广东省中医药局科研项目(20172119)

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    摘要:

    目的:观察肾康颗粒治疗慢性尿酸性肾病的临床疗效。方法:将80例慢性尿酸性肾病患者随机分为2组各40例。2组均给予西医常规治疗,观察组在西医常规治疗的基础上加用肾康颗粒治疗;对照组加用安慰剂治疗,疗程为3月。分别在治疗前后检测患者的中医症状积分、血清肌酐(SCr)、尿素氮(BUN)、尿酸(UA),血、尿β2-微球蛋白(β2-MG)的水平,评估患者的中医证候疗效。结果:治疗后,中医证候疗效总有效率观察组90.0%,对照组82.5%,2组比较,差异有统计学意义(P<0.05)。2组中医症状积分、SCr、BUN、UA、血β2-MG、尿β2-MG水平水平均较治疗前降低,且观察组治疗后中医症状积分、SCr、BUN、UA、血β2-MG、尿β2-MG水平低于对照组,差异均有统计学意义(P<0.05)。观察组大便异常2例,腹胀腹泻1例;对照组发生大便异常1例,腹胀腹泻2例,2组不良件事发生率比较,差异无统计学意义(P<0.05)。结论:肾康颗粒治疗慢性尿酸性肾病疗效显著,能降低尿酸,改善肾功能,延缓疾病的进展。

    Abstract:

    Objective:To observe the clinical effect of Shenkang granules for chronic uric acid nephropathy.Methods:Divided 80 cases of patients with chronic uric acid nephropathy into two groups randomly,40 cases in each group.Both groups received routine western medicine for treatment.The observation group additionally received Shenkang granules for treatment,while the control group additionally received placebos for three months.Detected scores of Chinese medicine symptoms and levels of serum creatinine(SCr), blood urea nitrogen(BUN),uric acid(UA),blood β2-microglobulin and urine β2-microglobulin(β2-MG)of patients before and after treatment in both groups.Evaluated the curative effect on Chinese medicine syndrome of patients.Results:After treatment,from the aspect of curative effect on Chinese medicine syndrome,the total effective rate was 90.0% in the observation group and was 82.5% in the control group,the difference being significant(P<0.05).Scores of Chinese medicine symptoms and levels of SCr,BUN,UA,blood β2-MG and urine β2-MG were obviously decreased when compared with those before treatment.Scores of Chinese medicine symptoms and levels of SCr,BUN,UA,blood β2-MG and urine β2-MG were remarkably lower than those in the control group,differences being significant(P<0.05).There were two cases of stool abnormity and one case of abdominal distention and diarrhea in the observation group.There was one case of stool abnormity and two cases of abdominal distention and diarrhea in the control group.No significant difference was found in the comparison of the incidence of adverse events between the two groups(P<0.05).Conclusion:Shenkang granules have a significant effect on treating chronic uric acid nephropathy,which can lower uric acid,improve renal function and delay the disease progression.

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谭秦湘,陈国姿,陈思诺,曾欢,刘旭生,朱丽芳.肾康颗粒治疗慢性尿酸性肾病临床研究[J].新中医,2018,50(5):90-94

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  • 在线发布日期: 2018-05-03
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