Objective：To observe the clinical effect of Guilu Erxian glue for primary osteoporosis(OP)with yin and yang deficiency of kidney syndrome.Methods：Divided 105 cases of patients with OP with yin and yang deficiency of kidney syndrome into two groups.The treatment group with 53 cases of patients was given oral administration of Guilu Erxian glue for treatment，while the control group with 52 cases of patients was additionally given alendronate sodium tablets and calcium carbonate and vitamin D3 tablets for treatment.The two groups were treated continuously for twelve months.Results：Seventy-eight cases of patients were followed up within twelve months，40 cases in the treatment group and 38 cases in the control group.After treatment，the absolute value of bone density，visual analogue score(VAS)of low back pain and scores of physical functioning(PF)，general health(GH)，vitality(VT)and mental health(MH)in the 36-item short form survey(SF-36)after treatment of six months and twelve months in the treatment group were compared respectively with those before treatment，differences being significant(P＜0.05).After treatment，there was no significant difference being found in the comparisons of the absolute value of bone density，VAS of low back pain and scores in SF-36(PF and MH)after treatment of six months and twelve months between the two groups(P＜0.05)，but the comparison of each score in SF-36(GH and VT)between the two groups showed significance in differences(P＜0.05).Conclusion：In the treatment of primary OP with yin and yang deficiency of kidney syndrome，Guilu Erxian glue can relieve the symptoms of low back pain and body pain，effectively improve the bone mineral density(BMD)and improve the quality of life of patients，whose efficacy is satisfying.