Objective： To observe the clinical effect of Gongying Baijiang tang combined with antibiotics for acute endometritis with damp-heat and blood stasis syndrome and itseffect on matrix metalloproteinase-9(MMP-9)and inflammatory factors of patients.Methods：Divided 138 cases of patients with acute endometritis with damp-heat and blood stasis syndrome into the control group and the study group randomly，69 cases in each group.The control group was given antibiotics for treatment，while the study group was given Gongying Baijiang tang combined with antibiotics.Compared the clinical effect in the two groups，recorded the endometrial thickness of patients before and after treatment and detected levels of serum MMP-9 and inflammatory factors including tumor necrosis factor-α (TNF-α)， C-reactive protein(CRP)，interleukins-2(IL-2)and interleukins-10(IL-10).Observed adverse reactions and calculated the recurrence rate.Results：The total effective rate was 92.75%in the study group and was 88.41%in the control group，there was no significance in the difference(P＜0.05).After treatment，the endometrial thickness of patients in the two groups were increased when compared with those before treatment(P＜0.05)，and the endometrial thickness of patients in the study group were thicker than those in the control group(P＜0.05).After treatment，MMP-9 levels in the two groups were decreased when compared with those before treatment(P＜0.05)，and MMP-9 levels in the study group were lower than those in the control group(P＜0.05).After treatment，levels of TNF-α and CRP in the two groups were decreased when compared with those before treatment(P＜0.05)，while levels of IL-2 and IL-10 were increased when compared with those before treatment(P＜0.05)； levels of TNF-α and CRP in the study group were lower than those in the control group(P＜0.05)，while levels of IL-2 and IL-10were higher than those in the control group(P＜0.05).No obvious adverse reaction was found in the two groups during the treatment.The recurrence ratewas 19.67%(12/61)in the control group and was 6.25%(4/64)in the study group，the difference being significant(P＜0.05).Conclusion：The therapy of Gongying Baijiang tang combined with antibiotics has significant effect in treating acute endometritis with damp-heat and blood stasis syndrome，which can effectively improve levels of serum MMP-9 and inflammatory factors of patients，promote the recovery of endometrium and decrease the recurrence rate.