Objective：To observe the clinical effect of Shuanghuanglian oral liquid combined with ribavirin granules for children with upper respiratory tract infection.Methods：Selected 100 cases of children with upper respiratory tract infection as study objects and divided them into the experiment group and the control group randomly，50 cases in each group.The experiment group received Shuanghuanglian oral liquid combined with ribavirin granules for treatment，while thecontrol group only received ribavirin granules.Compared the clinical effect in the two groups and observed the improvements of clinical symptoms and the occurrence of adverse reactions of children after treatment.Results：The total effective rate was 96.0%in the experiment group and was 80.0%in the control group，difference being significant(P＜0.05).The improvement of fever，red pharyngeal， aversion to cold，nasal obstruction and nasal discharge，cough，nausea and sneezing in the experiment group was better than that in the control group，differences being significant(P＜0.05).No significant difference was found in the comparison of the incidence of adverse reactions between the two groups(P＜0.05).Conclusion：The therapy of Shuanghuanglian oral liquid combined with ribavirin granules for children with upper respiratory tract infection is safe and effective，which can obviously improve symptoms of children.