Objective：To observe the clinical effect of injection needle scalpel combined with Tongbi tincture with hot compress for knee osteoarthropathy(KOA)with blood-stasis syndrome.Methods：Selected 80 cases of patients with KOA with blood-stasis syndrome，and divided them into the control group and the treatment group randomly according to stackeddigital table method，40 cases in each group.Two groups received injection needle scalpel for treatment.The treatment group received Tongbi tincture with hot compress for treatment three days after injection needle scalpel operation，once in 2 days for two weeks.Compared scores of western Ontario and McMaster university(WOMAC)osteoarthritis index and visual analogue scale(VAS)as well as the clinical effect in both groups.Detected levels of Interleukin(IL)-1 and IL-6 in serum before and after treatment.Results：After treatment，the total effective rate was 92.5%in the treatment group and 72.5%in the control group， difference being significant(P＜0.05).WOMAC osteoarthritis indexes including ankylosis and arthralgia and the score of restricted daily activities in two groups were all reduced when comparing with those before treatment(P＜0.01)，while these three indexes in the treatment group were all lower than those in the control group(P＜0.01).Scores of VAS in two groups were all reduced when comparing with those before treatment(P＜0.01).One and two weeks after treatment，score of VAS in the treatment group was lower than that in the control group(P＜0.01).Levels of IL-1 and IL-6 in serum in two groups were all reduced when comparing with those before treatment(P＜0.01).Levels of IL-1 and IL-6 in the treatment group was lower than those in the control group(P＜0.01).Conclusion：The therapy of injection needle scalpel combined with Tongbi tincture with hot compress in treating KOA with blood-stasis syndrome has a significant clinical effect，and can effectively improve clinical symptoms and relieve pain，and its mechanism may be related to the reduction of level of pro-inflammatory cytokines in serum.