Objective： To observe the effect of treatment and nursing of Chinese medicinesyndrome differentiation on quality of life of patients with irritable bowel syndrome(IBS).Methods：Selected 42 cases of IBS patients and gave them intervention of treatment and nursing of Chinese medicinesyndrome differentiation.After intervention，observed the improvement of clinical symptoms of patients and evaluated the quality of life of patients by Chinese gastroenteric disease patients reported outcome scale-irritable bowel syndrome scale(GEDPRO-IBS).Results：After intervention，scores and total scores of abdominal pain，abdominal distention，diarrhea and constipation of patients were decreased when compared with those before treatment，differences being significant(P＜0.01).After intervention，scores of independence，psychology，pain and discomfort， digestive function， stool， social relations and medical treatment of patients were decreased when compared with those before treatment，differences being significant(P＜0.01).No significant difference was found in the comparison of scores of energy and complexion before and after intervention(P＜0.05).Conclusion：Treatment and nursing of Chinese medicine syndrome differentiation has positive effect on improving quality of life of patients with IBS.