Autoimmune disease(AID)is a kind of disease with high heterogenicity，which is a progress that pathological immune responses was induced by antigen of oneself under the stimulation of various environmental factors.There is no definite theory to explain its pathogenesis at present.Neutrophils play an important role in non-specific immune system with functions of mediation， phagocytosis and sterilization.In recent years， neutrophil extracellular traps(NETs)， a novel mechanism for neutrophils，have attracted much attention in the study of autoimmune diseases.The commonly used immunosuppressant of chemical medicine in clinic can not radically control the occurrence and development of disease for its serious side effects，while the immunosuppressant of Chinese medicine is characterized by little side effects and good efficacy and is gradually applied widely in clinic.Based on the literature in recent years，the authors carried on the review respectively on the formation of NETs，the occurrence and development of NETs participating in autoimmune disease，basic researches on immunosuppressive effect of Chinese medicine and its clinical effect，to provide a reference for further study.