Nowadays in clinic,the Chinese medicine syndrome differentiation of gastroesophageal reflux disease is mainly characterized by the syndrome of heat stagnation in liver and stomach,and the syndrome of incoordination between liver and stomach.The treatment of the disease mostly focuses on clearing damp-heat while little takes deficiency syndrome into account,especially the effect of spleen deficiency syndrome on the occurrence and development of gastroesophageal reflux disease.The authors thought that the pathogenesis,clinical manifestation,syndrome differentiation and Chinese medicine treatment of gastroesophageal reflux disease are closely related to spleen deficiency syndrome.Gastroesophageal reflux disease will produce spleen deficiency syndrome in course of time,which further promotes the development of that disease.In the etiology, pathogenesis, and diagnosis and treatment of gastroesophageal reflux disease, the spleen deficiency syndrome plays an important role.