Objective：To analyze the the drugs using regularity of chronic cough in children based on Chinese medicine inheritance platformV2.5(TCMISS V2.5).Methods：Applied TCMISS to analyze the use frequency of various Chinese herbs in different prescriptions，character and taste，channel tropism，and association rules between drugs according to the Chinese herb prescription for chronic cough in children collected in China knowledge network，Wan fang and VIP database from2007-2017.Results：Among the 129 Chinese herb prescriptions which were screened out，there were a total of 300 Chinese herbs with 22 of the mused more than 15 times，and glycyrrhiza，balloon flower and bitter almond were the top three herbs which were most frequently used.The top three channel tropisms were the lung，spleen，and stomach meridian.The top three natures of the Chinese herbs were warm，neutral mild，and cold respectively，while the top three natures of the five tastes were bitter，sweet，and pungent.According to the descending order of occurrence of herb combination from high to low，the“glycyrrhiza and balloon flower”was followed by“balloon flower and bitter almond”and“ glycyrrhiza and bitter almond”.Conclusion：The commonly used Chinese herbs in treating children with chronic cough are mainly based on those ventilating lung，resolving phleg mand relieving cough and those nourishing the kidney and invigorating the lung.The channel tropism is mainly concentrated in the lungs，sp leen and stomach meridian，while four natures and five tastes mainly focus on natures of warm，neutral mild and cold，and tastes of bitter，sweet and pungent，in which glycyrrhiza，balloon flower，bitter almond，tangerine peel，poria cocos，periostracu mcicadae，radix peucedani，liriope，scutellaria，atractylodes，cortex mori are the core herbs in treating chronic cough in children.