Objective：To observe the clinical effect ofmodified Buyang Huanwu tang in treating patients with vasospastic angina and its effect on the expression of lipoprotein-associated phospholipase A2(Lp-PLA2)，hypersensitive C-reactive protein(hs-CRP)and growth differentiation factor-15(GDF-15).Methods：Divided 62 cases of patients with vasospastic angina into two groups randomly.The 30 cases in the controlgroup received the routine western medicine treatment including antiplatelet aggregation with aspirin， lipid-regulation and anti-inflammation with atorvastatin calciumtablets， dilation of coronary arteries with nitrate esters and alleviation in coronary artery spasmwith calcium channel blockers，while the 32 cases in the treatment group were additionally given modified Buyang Huanwu tang for treatment.One course of treatment for both groups lasted for 4 weeks.Respectively observed the differences of Chinese syndrome scores and the expression of Lp-PLA2，hs-CRP and GDF-15 in both groups before and after treatment，and compared the clinical effect in both groups.Results：The obvious effective rate of the clinicaleffect was 46.88%in the treatment group and 23.33%in the controlgroup，difference being significant(P ＜ 0.01)；the total effective rate was 93.75%in the treatment group and 90.00%in the control group，difference being insignificant(P ＞ 0.05).After treatment，Chinese syndrome scores in both groups were significantly lower than those before treatment(P ＜ 0.01)；and Chinese syndrome scores in the treatment group were decreased more evidently than those in the control group(P ＜ 0.05).After treatment，the expression of Lp-PLA2，hs-CRP and GDF-15 of patients in both groups was significantly lower than that before treatment(P ＜ 0.05)；and each index above in the treatment group was reduced more obviously than that in the control group( P ＜0.05).No adverse reactions occurred in both groups during treatment.Conclusion：On the basic of routine western medicine treatment，the combination of modified Buyang Huanwu tang can significantly improve the clinical symptoms of patients with vasospastic angina，promote the clinical effect，and its functional mechanismmay be related to reducing the vascular inflammatory response，improving coronary artery spasm.