Objective：To observe the clinicaleffect of Daqinjiao tang combined with early comprehensive rehabilitation for post-stroke spastic paralysis of the upper extremities.Methods：Selected 136 cases of patients with post-stroke spastic paralysis of the upper extremities，and divided the min to the control group and the observation group randomly，68 cases in each group.The control group was given early comprehensive rehabilitation for treatment，while the observation group additionally received Daqinjiao tang for treatment.After treatment for 4 weeks，compared the improvement rate of spasmin the upper extremities of both groups，the scores of Fugl-Meyer assessment(FMA)，modified Barthel index(MBI)and scores of National Institute of Health stroke scale(NIHSS)in both groups before and after treatment，and detected changes of the content of neuron-specific enolase(NSE)and homocy steine(Hcy)in serum.Results：After treatment，the improvement rate of spasmin the upper extremities was 70.59% in the observation group and 51.47% in the control group，difference being significant( P ＜ 0.05).After treatment，scores of FMA and MBI in both groups were higher than those before treatment( P ＜0.05)，and scores of NHISS were lower than those before treatment(P ＜ 0.05)；scores of FMA and MBI in the observation group were increased more significantly than those in the control group(P ＜ 0.05)，and the score was of NHISS was decreased more significantly than that in the controlgroup(P ＜ 0.05).After treatment，the contents of Hcy and NSE in serumwere respectively lower than those before treatment(P ＜ 0.05)，and the contents of Hcy and NSE in serumof the observation group were reduced more evidently than those of the controlgroup( P ＜0.05).Conclusion：Daqinjiao tang combined with early comprehensive rehabilitation can improve the post-stroke spastic status of the upper extr emities and upper extremity function of patients，alleviate nerve injury and promote the living ability of patients，which is significantly meaningful for post-stroke extremity remodeling.