Objective：To observe the clinical effect of Bushen Tianjing Yisuiprescription combined with western medicine for Alzheimer's disease(AD).Methods：Divided 94 cases of AD patients with syndrome of kidney marrowdeficiency into the treatment group and the control group according to randomnumber table method，47 cases in each group.The treatment group received Bushen Tianjing Yisui prescription and donepezil hydrochloride tablets for treatment，while the control group received donepezilhydrochloride tablets.The treatment of the two groups lasted for six months.Compared the curative effect in the two groups.Observed the changes of scores of cognitive function which includes the Alzheimer's disease assessment scale-cognitive portion(ADAS-Cog)and severe impairment battery(SIB)，the changes of scores of behavioral ability which includes behavior rating scale for dementia(BEHAVE-AD)and activities of daily living scale(ADL)as well as the changes of scores of negative emotion which includes Hamilton anxiety scale(HAMA)and Cornell scale for depression in dementia(CSDD)of patients before and after treatment.Results：After treatment of six months，the total effective rate was 93.62%in the treatment group，higher than that in the control group，which was 76.60%，the difference being significant( P ＜0.05).ADAS-Cog scores in the two groups were decreased when compared with those before treatment，while the SIB scores were increased when compared with those before treatment，differences being significant(P ＜ 0.05).ADAS-Cog score in the treatment group was lower than that in the control group( P ＜0.05).Scores of BEHAVE-AD，ADL，HAMA and CSDD in the two groups were all decreased when compared with those before treatment，differences being significant(P ＜ 0.01).The above four scores in the treatment group were lower than those in the control group( P ＜0.01).Conclusion：Bushen Tianjing Yisui prescription can not only effectively improve cognitive function and behavioral ability of AD patients，but also relieve negative emotions as anxiety and depression，and its combiniation of donepezil hydrochloride tablets can be a treatment for AD in clinicalpractices.