Objective：To observe the clinical effect of oraladministration of Shegan Mahuang tang combined with aerosol inhalation treatment of western medicine for bronchial asthma(BA)at acute attack stage and the effect on levels of IL-6，TNF-α and IgE in serum.Methods：Divided 80 cases of patients with BA at acute attack stage into the controlgroup and the observation group randomly by means of random number table，40 cases in each group.The control group was treated with aerosol inhalation of budesonide suspension and salbutamol solution on the basis of anti-infection， oxygen absorption，water-electrolyte supp lement and the treatment of relieving cough resolving phlegm，while the observation group was additionally given oralad ministration of Shegan Mahuang tang for treatment.The treatment in both groups continuously lasted for 15 days as one course.Observed the clinicaleffect，changes of the levels of IL-6，TNF-α and IgE in serum，changes in major clinical symptoms and signs and adverse drug reactions in the two groups.Results：The total effective rate was 97.50%in the observation group and 77.50%in the controlgroup，difference being significant(P ＜ 0.05).After treatment，the changes of levels of IL-6，TNF-α and IgE in serum were lower than those before treatment(P ＜ 0.05)，and the levels of IL-6，TNF-α and IgE in the observation group were obviously lower than those in the control group( P ＜0.05).After treatment，the major symptoms and scores of physical signs in the two groups were all clearly decreased when compared with those before treatment( P ＜0.05).The scores of symptoms and signs of patients in the observation group were lower than those in the controlgroup( P ＜0.05).There were no obvious adverse reactions in both groups.Conclusion：On the basis of western medicine treatment，the therapy of oraladmini stration of Shegan Mahuang tang combined with aerosol inhalation treatment of western medicine for BA acute attack can effectively improve the clinical symptoms of patients and reduce the levelof inflammatory factors and it does not increase the incidence of adverse reactions and is worthy of clinicalapplication.