Objective：To observe the clinical effect of Chaihu Hugan tang combined with entecavir dispersable tablets for chronic hepatitis B.Methods：Divided 100 cases of patients with chronic hepatitis B into the controlgroup and the observation group randomly， 50 cases in each group.The control group was treated with entecavir dispersable tablets， while the observation group was additionally given Chaihu Hugan tang based on the treatment of the control group.The two groups continuously received treatment for six months.Recorded the improvement time of gastrointestinal symptomsin patients，compared liver function indexes including alanine transaminase(ALT)， aspartate transaminase(AST)， total bilirubin(TBil)and gamma glutamyl transferase(GGT)，and compared and analyzed the total effective rate of treatment in the two groups before and after treatment.Results：The improvement time of abdominal distension，poor appetite，nausea and vomiting in the observation group was shorter than that in the control group(P ＜ 0.05).After treatment，the levels of ALT，AST，TBil and GGT in the two groups were decreased when compared with those before treatment，differences being significant(P ＜ 0.05).The levels of ALT，AST，TBil and GGT in the observation group were all lower than those in the control group，differences being significant( P ＜ 0.05).The total effective rate was 84.0%in the observation group and was 60.0%in the control group，the difference being significant( P ＜0.05).Conclusion：The additionalapplication of Chaihu Hugan tang based on the treatment of entecavir dispersable tablets can effectively improve the clinicalsymptoms of patients with chronic hepatitis B，protect liver function and improve the therapeutic effect.