Objective： To evaluate the improvement of pressurized cold therapy combined with external application of Sihuang powder for ankle acute soft tissue injury.Methods：Divided 180 cases of patients with ankle acute soft tissue injury into two groups randomly，90 cases in each group.The treatment group was given pressurized cold therapy combined with external application of Sihuang powder and external fixation of ankle guard for treatment，while the control group was given external application of voltaren ointment and external fixation of ankle guard.The two groups received treatment for two weeks.Observed and recorded the degree of pain and swelling respectively before treatment，after treatment of 14 days and three months after treatment.Results：On the 14 th day of treatment and after three months of follow-up，VAS scores and the swelling degrees of patients in the two groups were improved when compared with those before treatment( P ＜0.05)；and the improvement of VAS scores and the swelling degree in the treatment group was more obvious than those in the controlgroup at the same period，differences being significant(P ＜ 0.05).Conclusion：The therapy of pressurized cold therapy combined with externalapplication of Sihuang powder can effectively improve the degree of pain and swelling of patients with ankle acute soft tissue injury，which has good clinicaleffect.