Objective：To observe the clinical effect of argon-helium cryoablation combined with Chinese medicine for primary liver cancer at different Barcelona Clinic Liver Cancer(BCLC)stages.Methods：Reviewed medical records，divided 51 cases ofprimary liver cancer into the BCLC stage-A group，the BCLC stage-B group and the BCLC stage-C group，respectively analyzed progression free survival(PFS)，overall survival(OS)and the survival rate in the 6th month，12 th month and 24 th month of the three groups，and compared the differences of PFS and OS among the three groups via Log-rank test.R e s u lts：The median PFS of primary liver cancer in the BCLC stage-A group，the BCLC stage-B group and the BCLC stage-C group was(14.0± 3.0)months，(7.0± 1.9)months and(7.0± 2.0)months respectively，which were processed by statistics，difference being significant( P ＜0.05)；the median OS in the BCLC stage-A group，the BCLC stage-B group and the BCLC stage-C group was(52.0±11.2)months，(32.0±7.1)months and(33.0± 5.4)months respectively，and there was significant difference being found in the comparison of OS among the three groups( P ＜0.05)；the survival rate in the 6 th month，12 th month and 24 th month of the BCLC stage-A group，the BCLC stage-B group and the BCLC stage-C group was 100%，91.7%，75.0%，92.9%，78.6%，57.1%，96.0%，76.0%，44.0%respectively.There was significant difference being found in the survival rate of primary liver cancer at different stages in the 6 th month，12 th month and 24 th month( P ＜0.05).Through multivariate Cox regression analysis，at the BCLC stage A and B，the scores of 80 and 90 in KPS，the times of freezing and the quantity of cryoprobe were the protective factors for prognosis，while a history of cirrhosis and the scores of 60 and 70 in KPS were the dangerous factors for prognosis.C o n c lu s io n：The treatment of argon-helium cryoablation combined with Chinese medicine can prolong the survival time of primary liver cancer，and the combination therapy regimen has advantages.