芡实合剂治疗脾肾阳虚型狼疮性肾炎临床观察
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R593.24+2

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河南省科技攻关计划项目 (172102310287);河南省中医科研专项课题(2017ZY1014)


Clinical Observation on Semen Euryales Mixture for Patients with Lupus Nephritis of Yang Deficiency of Spleen and Kidney Type
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    摘要:

    目的:观察芡实合剂治疗狼疮性肾炎(LN)脾肾阳虚证的临床疗效。方法:将LN患者80例按随机数字表法分为治疗组和对照组各40例,对照组予醋酸泼尼松片、吗替麦考酚酯片口服治疗,治疗组在对照组治疗的基础上联合剂芡实合剂治疗,2组疗程均为3月;观察2组临床疗效,实验室指标血沉(ESR)、C-反应蛋白(CRP)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、补体3(C3)、补体4(C4)、抗双链DNA抗体(抗dsDNA),24h尿蛋白定量,系统性红斑狼疮疾病活动指数(SLE-DAI),以及治疗前后泼尼松的用量情况。结果:显效率、总有效率治疗组分别为42.5%、87.5%,对照组分别为25.0%、67.5%,2组比较,差异有统计学意义(P<0.05)。治疗后2组ESR、IgG、IgM、C3、C4、抗ds-DNA、24h尿蛋白定量、SLE-DAI等指标均较治疗前明显改善(P<0.05,P<0.01);且治疗组ESR、IgM、C3、抗ds-DNA、24h尿蛋白定量、SLEDAI等改善均优于对照组(P<0.05)。疗程结束后,治疗组泼尼松用量低于对照组,差异有统计学意义(P<0.05)。不良反应发生率治疗组为22.5%,对照组为87.5%,2组比较,差异有统计学意义(P<0.05)。结论:芡实合剂联合西药治疗LN脾肾阳虚证患者能提高临床疗效,减少醋酸泼尼松用量,且不良反应少。

    Abstract:

    Objective:To observe the clinical effect of semen euryales mixture for patients with lupus nephritis(LN)with syndrome of yang deficiency of spleen and kidney.Methods:Divided 80 cases of patients with LN into the treatment group and the controlgroup according to the randomnumber table method,40 cases in each group.The control group was treated with oral administration of prednisone acetate tablets and mycophenloate mofetil tablets,while the treatment group was additionally treated with semen euryales mixture based on the treatment of the control group.The treatment of both groups lasted for three months.Observed the clinical effect, laboratory indicators including erythrocyte sedimentation rate(ESR),C-reactive protein(CRP), immunoglobulin A(IgA), immunoglobulin G(IgG), immunoglobulin M(IgM), complement 3(C3),complement 4(C4), anti-double strand DNA antibody(anti-dsDNA), 24-hour urine protein value(24hrUprV)and systemic lupus erythematosus-disease activity index(SLE-DAI),and dosage of prednisone before and after treatment in the two groups.Results:The obvious effective rate and the total effective rate was 42.5%and 87.5%respectively in the treatment group,while was 25.0% and 67.5% respectively in the control group,the difference being significant(P < 0.05).After treatment,levels of ESR,IgG,IgM,C3,C4,anti-dsDNA,24hrUprV and SLE-DAI in the two groups were significantly improved when compared with those before treatment(P < 0.05,P < 0.01).The improvement of ESR,IgM,C3,anti-dsDNA,24hrUprV and SLE-DAI in the treatment group were superior to those in the control group( P <0.05).After treatment,the dosage of prednisone in the treatment group was lower than that in the control group,the difference being significant( P < 0.05).The incidence of adverse reactions was 22.5%in the treatment group and 87.5%in the control group,the difference being significant( P <0.05).Conclusion:The therapy of semen euryales mixture combined with western medicine for patients with LN with syndrome of yang deficiency of spleen and kidney can improve the clinical effect and decrease the dosage of prednisone acetate with less adverse reactions.

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李松伟,冯福海,郭洪涛,王子华,王荷堵.芡实合剂治疗脾肾阳虚型狼疮性肾炎临床观察[J].新中医,2018,50(7):150-153

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  • 在线发布日期: 2018-07-09
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