Objective：To observe the clinical effect of semen euryales mixture for patients with lupus nephritis(LN)with syndrome of yang deficiency of spleen and kidney.Methods：Divided 80 cases of patients with LN into the treatment group and the controlgroup according to the randomnumber table method，40 cases in each group.The control group was treated with oral administration of prednisone acetate tablets and mycophenloate mofetil tablets，while the treatment group was additionally treated with semen euryales mixture based on the treatment of the control group.The treatment of both groups lasted for three months.Observed the clinical effect， laboratory indicators including erythrocyte sedimentation rate(ESR)，C-reactive protein(CRP)， immunoglobulin A(IgA)， immunoglobulin G(IgG)， immunoglobulin M(IgM)， complement 3(C3)，complement 4(C4)， anti-double strand DNA antibody(anti-dsDNA)， 24-hour urine protein value(24hrUprV)and systemic lupus erythematosus-disease activity index(SLE-DAI)，and dosage of prednisone before and after treatment in the two groups.Results：The obvious effective rate and the total effective rate was 42.5%and 87.5%respectively in the treatment group，while was 25.0% and 67.5% respectively in the control group，the difference being significant(P ＜ 0.05).After treatment，levels of ESR，IgG，IgM，C3，C4，anti-dsDNA，24hrUprV and SLE-DAI in the two groups were significantly improved when compared with those before treatment(P ＜ 0.05，P ＜ 0.01).The improvement of ESR，IgM，C3，anti-dsDNA，24hrUprV and SLE-DAI in the treatment group were superior to those in the control group( P ＜0.05).After treatment，the dosage of prednisone in the treatment group was lower than that in the control group，the difference being significant( P ＜ 0.05).The incidence of adverse reactions was 22.5%in the treatment group and 87.5%in the control group，the difference being significant( P ＜0.05).Conclusion：The therapy of semen euryales mixture combined with western medicine for patients with LN with syndrome of yang deficiency of spleen and kidney can improve the clinical effect and decrease the dosage of prednisone acetate with less adverse reactions.