Objective： To observe the clinical effect of wheat-grain size cone moxibustion for primary dysmenorrhea.Methods：Divided 120 cases of patients with primary dysmenorrhea into the observation group and the control group randomly，60 cases in each group.The observation group received wheat-grain size cone moxibustion for treatment once a day fromone week before menstruation to the onset ofmenstruation.The controlgroup received ibuprofen sustained release capsules when dysmenorrhea occurred.After treatment， observed the pain degree， duration of dysmenorrhea and improvement of concomitant symptoms in the two groups.Results：The total effective rate was 96.7%in the observation group and was 76.7%in the control group，the difference being significant(P ＜ 0.05).After treatment，scores of visual analogue scale(VAS)，duration of concomitant symptoms of dysmenorrhea(RSS-COX1)and degree of concomitant symptoms(RSS-COX2)were decreased when compared with those before treatment( P ＜0.01).Scores of VAS，RSS-COX1 and RSS-COX2 in the observation group were lower than those in the control group( P ＜0.01).During the follow-up，the comparisons of VAS，RSS-COX1 and RSS-COX2 between the two groups showed significance in the difference( P ＜0.01).After treatment，the duration of pain in the two groups was shortened when compared with that before treatment(P ＜ 0.01).The duration of dysmenorrhea in the observation group was shorter than that in the controlgroup( P ＜0.01).The comparison of the duration of dysmenorrhea between the two groups during the follow-up showed significance in the difference( P ＜0.01).Conclusion：The therapy of wheat-grain size cone moxibustion is superior to that of ibuprofen sustained release capsules in relieving the pain degree，shortening the duration of pain and improving concomitant symptoms of dysmenorrhea of patients with primary dysmenorrhea.The therapy also has short termeffect and long termeffect.