Objective： To observe the clinical effect of Chinese medicine of warming yang， resolving turbidity and transforming dampness combined with bloodletting puncture for acute gouty arthritis(AGA)，and discuss its mechanismfromthe aspect of immunology.Methods：Divided 120 cases of patients into two groups，60 cases in each group.The observation group received Chinese medicine of warming yang，resolving turbidity and transforming dampness combined with bloodletting puncture for treatment，while the control group received diclofenac sodium sustained-release tablets.Observed the clinical effect， symptoms scores， pain scores of visual analogue scales(VAS)and laboratory indicators including erythrocyte sedimentation rate(ESR)， C-reactive protein(CRP)，uric acid(UA)， interleukins-1β (IL-1β )and tumor necrosis factor- α(TNF-α )in the two groups.Results：The cured and remarkably effective rate was 76.7%in the observation group and 60.0%in the control group，the difference being significant(P ＜ 0.05).After treatment，the comparisons of symptoms scores and pain scores of VAS between the two groups showed significance in differences(P ＜ 0.05).After treatment，in addition to ESR and CRP，the comparisons of UA，IL-1β and TNF-α between the two groups showed significance in differences( P ＜ 0.05，P ＜ 0.01).Conclusion：The therapy of Chinese medicine of warming yang，resolving turbidity and transforming dampness combined with bloodletting puncture for AGA is better than that of diclofenac sodium sustained-release tablets.The therapy has an effect of adjusting humoral immunity of patients fromthe aspect of the immune mechanism.