Objective： To observe the clinical effect of acupuncture combined with Xuefu Zhuyu ta ng for migraine.Methods：Selected 200 cases of patients with migraine，and divided theminto the experiment group and the control group according to the randomnumber table method，100 cases in each group.The experiment group was treated with acupuncture combined with Xuefu Zhuyu tang，while the control group was treated with flunarizine hydrochloride capsules.The treatment of the two groups lasted for one month.Compared and analyzed the clinical effect，and observed the changes of scores of verbal rating scale(VRS)for pain，visual analogue scale(VAS)and SF-36 scale before and after treatment.Results：The total effective rate was 92.00%in the experiment group and was 70.00%in the controlgroup，the difference being significant( P ＜0.05).After treatment，scores of VRS and VAS in the two groups were decreased when compared with those before treatment，differences being significant(P ＜ 0.05).Scores of VRS and VAS in the experiment group were lower than those in the control group，differences being significant(P ＜ 0.05).After treatment，the eight dimensions of SF-36 scale were increased in the two groups when compared with those before treatment，differences being significant(P ＜ 0.05).The eight dimensions of SF-36 scale in the experiment group were higher than those in the controlgroup，differences being significant( P ＜0.05).Conclusion：The therapy of acupuncture combined with Xuefu Zhuyu tang for migraine has remarkable clinical curative effect，which can improve the headache condition of patients and improve the quality of life.Keywords：Migraine；Acupuncture；Xuefu Zhuyu tang；Pain score；Quality of life