Objective：To observe the clinicaleffect of the deep acupuncture at Jiajipoint under the guidance of CT for lowback pain with blood stasis syndrome and its effect on the level of substance P in serum.Methods：Selected 96 cases of patients with lowback pain admitted in our hospital，and divided theminto two groups randomly，48 cases in each group.The two groups received oral administration of diclofenac sodiumsustained release tablets and ibuprofen tablets and was given Mckenzie rehabilitation therapy.The treatment group was additionally given deep acupuncture at Jiajipoint based on CT，while the controlgroup was additionally given traditionalacupuncture of Jiajipoint.The treatment of both groups lasted for four weeks.Compared the visualanalogue scores(VAS)and scores of Oswestry dability index(ODI)scale，and detected levels of substance P in serumbefore and after treatment.Results：After treatment，VAS score in the treatment group was lower than that in the control group，and the decrease of VAS score in the treatment group was greater than that in the control group.After treatment，each score of the factor in ODIscale in the treatment group was lower than that in the controlgroup.After treatment，the levelof substance P in serumin the treatment group was lower than that in the control group，and the decrease of the level of substance P in serumwas greater than that in the control group，differences being significant( P ＜0.01).The total effective rate was 95.83%in the treatment group，higher than that of 79.17%in the control group，the difference being significant( P ＜0.05).Conclusion：Based on the acupuncture at Jiaji point under the guidance of CT for lowback pain can alleviate pain，promote the recovery of function and improve the clinical curative effect.The reduction in levelof substance P in serummay be related to the curative effect.