Objective：To observe the clinical effect of acupuncture at five Shu acupoints combined with routine western medicine for cardiac neurosis.Methods：Divided 100 cases of patients with cardiac neurosis into the acupuncture-medicine group and the western medicine group randomly，50 cases in each group.The western medicine group was given oryzanol，vitamin B 1 ，diazepamand propranolol for treatment，while the acupuncture-medicine group received the acupuncture at five shu acupoints(Xinshu，Feishu，Pishu，Ganshu，Shenshu)combined with routine western medicine.The two groups both took 3 courses of treatment in total， 10 days as one course.After treatment， observed the improvements of Chinese medicine symptoms in both groups，compared the scores of Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD)， and evaluated the clinical effect in both groups.Results： After treatment， the scores of Chinese medicine symptoms in both groups were lower than those before treatment(P ＜ 0.01)，and the scores of Chinese medicine symptoms in the acupuncture-medicine group were lower than those in the western medicine group( P ＜0.01).The total effective rate was 88.0%in the acupuncture-medicine group and 74.0%in the western medicine group，difference being significant( P ＜0.05).After treatment，the scores of HAMA and HAMD in both groups were lower than those before treatment(P ＜ 0.01)，and the scores of HAMA and HAMD in the acupuncture-medicine group were lower than those in the western medicine group( P ＜0.01).Conclusion：Acupuncture at five shu acupoints combined with routine western medicine in treating patients with cardiac neurosis can promote the clinical effect，improve the clinical symptoms and alleviate the degree of anxiety and depression.