Objective：To observe the clinicaleffect of point application of Fructus Evodiae powder plus Succus Rhizomatis Zingiberis in preventing and treating post-operative nausea and vomiting(PONV)after total knee arthroplasty(TKA).Methods：Divided 240 cases of patient with TKA into the observation group and the control group randomly，120 cases in each group.The controlgroup was treated with granisetron and received routine nursing after operation.According to the grading standard of PONV reaction fromworld health organization，methoxychloropramine tablets were selected to prevent vomiting.The observation group was additionally treated with point app lication of Fructus Evodiae powder p lus Succus Rhizomatis Zingiberis based on the treatment of the control group.Recorded the occurrence of PONV and the use ofmethoxyclopramide tablets in the two groups after treatment.Results：At the 6 th and 24 th hours after operation，the incidence of nausea and vomiting in the observation group was lower than that in the control group and the degree of nausea and vomiting was lower，differences being significant( P ＜0.05， P ＜0.01).At the 48 th hour after operation，there was no significant difference being found in the comparisons of the incidence of nausea and vomiting and the degree of nausea and vomiting between the two groups(P＞0.05).At the 6 th hour after operation，the comparison of the use rate ofmethoxyclopramide tablets between the two groups showed significance in the difference( P ＜0.05).At the 24 th and 48 th hours after operation，there was no significant difference being found in the comparison of the use rate of methoxyclopramide tablets between the two groups(P＞ 0.05).Conclusion：The therapy of point application of Fructus Evodiae powder plus Succus Rhizomatis Zingiberis can reduce the occurrence of PONV in patients with TKA and reduce the degree of PONV.