Objective： To explore the mechanismof Hewei Fanliukang on the gastric mucosa of rats with bile reflux gastritis.Methods：Established rat models of bile reflux gastritis by gavage of reflux fluid.Forty rats were randomly divided into the blank group，the model group，the alumino phosphate gel group and the Hewei Fanliukang group.Detected the protein expressions of Iκ B kinaseβ (IKKβ)in gastric mucosalepithelium by Western blot，and IKKβ expression contents in gastric mucosa by RT-PCR.Results：Compared with the blank group，the expression levels of IKKβ protein and IKKβ m RNA in the gastric mucosa in the modelgroup were significantly increased( P ＜0.05).Compared with the modelgroup，the expression levels of IKKβ protein and IKKβ m RNA in the gastric mucosa of rats in the Hewei Fanliukang group and the alumino phosphate gel group were significantly decreased( P ＜0.05， P ＜0.01).Compared with the aluminumphosphate gel group，there was no significant difference being found in the Hewei Fanliukang group.Conclusion：Hewei Fanliukang may effectively improve gastric mucosal inflamm ation by reducing gene expression of IKKβ.