Objective：To explore the generating effect of epigallocatechin-3-gallate(EGCG)on amyloid-β peptide(Aβ )of modelmice with Alzheimer's disease(AD)induced by D-galactose.Methods：Divided 60 cases of mice from Kunmingrandomly into the control group，the model group，the VE positive group，the EGCG groups of low，middle and high dose，10 cases in each group.After establishing the modelmice with AD by injection of D-galactose，the control group and the model group were given equivalent double distilled w ater by gavage.The VE positive group was given 5.6%VE by gavage once a day.The EGCG groups of low，middle and high dose were respectively given 2m g/kg 0.04%EGCG，4m g/kg 0.08%EGCG，6m g/kg 0.12%EGCG by gavage once a day.After continuously treating for 28 days，observed the changes of animal behaviors by the step-through test and Morris w ater m aze test， detected levels of interleukins-2(IL-2)， interleukins-6(IL-6)，tumor necrosis factor-α (TNF-α )and Aβ in brain homogenate ofmice by ELISA method，and observed the changes of neurons in hippocampus of mice by hem atoxylin-eosin staining.Results：EGCG can obviously prolong the step-dow n latency，reduce the error frequency of step-dow n，shorten the passing time through m aze and reduce the error frequency of entering dead end of the modelmice with AD，and it can obviously relieve the injury of neurons in hippocampus of model mice with AD induced by D-galactose and reduce the expression levels of IL-6，TNF-α and Aβ ，differences being significant( P ＜0.05).Conclusion：EGCG possibly can inhibit the apoptosis of neurons by reducing the content of Aβ of bain in the modelmice with AD induced by D-galactose，so as to improve the learning and memory impairment.