Objective：To observe the curative effect of Sofren injection and Guanxin Shutong capsules com bined with routine therapy for patients with restenosis after percutaneous coronary intervention(PCI).Methods：Selected 70 cases of patients with restenosis after PCIand divided theminto two groups according to random num ber table.The two groups were given routine western medicine such as aspirin，clopidogrel and sim vastatin orally，while the control group was given Sofren injection and Guanxin Shutong capsules additionally.The treatment for both groups lasted for 2 courses，15 days per course.Observed the changes of clinical symptoms， endothelial microparticles(EMPs)in serum， soluble intercellular adhesion molecule-1(sICAM-1)，superoxide dismutase(SOD)and m alonaldehyde(MDA)before and after treatment.A reexamination by coronary angiography was given 6 months later.Results：The total effective rate was 95.0%in the observation group and 60.0%in the control group，difference being significant( P ＜0.01).The symptomscores of chest pain，chest distress，shortness of breath，hypodynamia and dry mouth as well as the total scores in the observation group were all decreased when compared with those before treatment( P ＜0.05).The symptoms of chest pain and chest distress in the control group were both improved( P ＜0.05)，and there was no obvious improvements being found in the symptoms of shortness ofbreath，hypodynamia and dry mouth( P ＞0.05).There were significant differences being found in the comparisons between each symptomscore and the total score( P ＜0.05).There were significant differences being found in the comparisons of levels of SOD，MDA，EMPs and s ICAM-1 in the two groups with those before treatment( P ＜0.05).The SOD level in the observation group was higher than that in the control group，and the levels of MDA，EMPs and sICAM-1 were lower than those in the control group，differences being significant( P ＜0.05).The incidence of coronary restenosis was 7.5%in the observation group and 30.0% in the control group，difference being significant( P ＜0.05).The observation group was superior to the control group in improving the loss of blood vessel diameter and lumen area net gain.Conclusion：The application of Sofren injection and Guanxin Shutong capsules com bined with the three-level treatment strategy of western medicine can reduce the symptoms of angina pectoris in patients after PCI.Compared with western medicine alone，it does not increase adverse reactions but improves compliance and quality of life of patients.With a significant curative effect and good safety，it em bodies the treatment advantages of single Chinese herbs and the compound prescriptions in multiple paths，sections and target，which is of greatsignificance in prevention and treatmentof coronary heartdiseasewith restenosis afterPCI.