Objective： To observe the curative effect of Tongluo Huoxue tang combined with venous urokinase throm bolysis for acute cerebral infarction and its effect on levels of toll-like receptor-4(TLR4)and interleukin-1β (IL-1β )in peripheral blood mononuclear cells.Methods：Divided 106 cases of patients with acute cerebral infarction into two groups randomly，53 cases in each group.The controlgroup was treated with venous urokinase throm bolysis，while the study group was treated with Tongluo Huoxue tang com bined with venous urokinase throm bolysis.The two groups continuously received treatment for four weeks.Compared the clinicaleffect after treatment in the two groups，recorded scores of National Institute of Health stroke scale(NIHSS)and the Barthel index in the two groups before and after treatment，and detected levels of hemorheological indexes and levels of TLR4 and IL-1β in peripheral blood mononuclear cells in the two groups before and after treatment.Results：After treatment，the total effective rate was 90.57% in the study group，higher than than of 69.81%in the control group，the difference being significant( P ＜0.05).The scores of NIHSS in the two groups were decreased when compared with those before treatment( P ＜0.01)，and the Barthel index scores were increased( P ＜0.01).The score of NIHSS in the study group was lower than that in the control group( P ＜0.01)，and the Barthel index score was higher( P ＜0.01).Levels of the whole low blood viscosity，whole high blood viscosity，platelet aggregation rate and hem atocrit in the two groups were decreased when compared with those before treatment( P ＜0.01).Each index above in the study group was lower than that in the control group( P ＜0.01).Levels of TLR4 and IL-1β in peripheral blood mononuclear cells of the two groups were decreased when compared with those before treatment( P ＜0.01)，and the above two indexes in the study group were lower than those in the control group( P ＜0.01).Conclusion：The therapy of Tongluo Huoxue tang com bined with venous urokinase throm bolysis has a significant curative effect in treating acute cerebral infarction，which caneffectively alleviate the neurological deficits of patients，enhance the activity of daily living， improve hemorheology and reduce inflamm atory response.