Objective： To discuss the effect of Shenqi Wenyuan tang com bined with low-dose Youjiale on thyroid hormone and the quality of life of patients with hypothyroidismof spleen-kidney yang deficiency type.Methods：Selected 96 cases of patients with hypothyroidismof spleen-kidney yang deficiency type，and divided theminto the observation group and the control group randomly，48 cases in each group.The control group was given Youjiale，while the observation group was given Shenqi Wenyuan tang com bined with low-dose Youjiale.Compared the levels of thyroid hormone in serum，dimensional scores of quality of life(QOF)and clinical syndrome scores in Chinese medicine of both groups before and after treatment， and compared the clinical effect and occurrence of adverse reactions.Results： The total effective rate was 95.56%in the observation group，significantly higher than 79.55%in the controlgroup，difference being significant( P ＜0.05).Before treatment， comparing the levels of thyroid stimulating hormone(TSH)， free triiodothyronine(FT 3 )， free tetraiodothyronine(FT 4 )，total thyroxine(TT 4 )，thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TGAb)，scores of QOL in 8 dimensions and clinical syndrome scores in Chinese medicine of both groups，there were no significant differences being found( P ＞ 0.05).After 3 courses of treatment，the levels of TSH and TGAb，values of bodily pain(BP)and clinical syndrome scores in Chinese medicine in both groups were all decreased，the levels of FT 3 ，FT 4 and TT 4 were all increased，and scores of QOL in other dimensions were increased to different extent；the level of TPOAb in the observationgroup was decreased；there were significant differences being found( P ＜0.05， P ＜0.01).After treatment，the levels of TSH，TGAb and TPOAb，values of BP and clinical syndrome scores in Chinese medicine of the observation group were all lower than those in the control group，the levels of FT 3 ，FT 4 and TT 4 were all higher then those in the control group，and scores of QOL in other dimensions were all higher than those in the control group，differences being significant( P ＜0.05).After treatment，the incidence of adverse reactions was 9.09%in the control group and 11.11%in the observation group respectively，difference being insignificant(χ 2 =0.06， P ＞ 0.05).Conclusion：ShenqiWenyuan tang com bined with low-dose Youjiale for patients with hypothyroidismof spleen-kidney yang deficiency type has good clinical effect.With relatively high safety，it can improve the clinical symptoms and the level of thyroid hormone in serumof patients and promote the quality of life，which has better clinicaleffect than the simple application of Youjiale.