Logistic Regression Analysis on Non-alcoho lic Fatty Pancreas Disease and Chinese Medicine Constitution Type and Related Risk Factors
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摘要:
目的:探讨非酒精性脂肪胰(NAFPD)患者中医体质分布规律及与发病相关糖脂代谢因素的关系。方法:对宁波地区1604例入组人群(NAFPD者946例,健康人群658例)进行中医体质判定,运用Logistic回归法分析疾病易感体质、易感体质与发病相关糖脂代谢因素的关联性。结果:NAFPD患者中痰湿质、血瘀质、气虚质分布较多( P <0.05),三者均为NAFPD发病易感体质因素( P <0.05),平和质分布较少( P <0.05)。痰湿质与NAFPD者的体质指数、伴发2型糖尿病、糖化血红蛋白水平呈正相关;血瘀质与NAFPD加重、伴发非酒精性脂肪肝正相关,与脂联素水平负相关;气虚质与相关因素均无明显相关性。结论:痰湿质、血瘀质、气虚质为NAFPD患者高频体质与发病易感因素,其中痰湿质与肥胖、糖代谢紊乱有关,血瘀质与脂代谢紊乱、内脏脂质沉积加重有关。
Abstract:
Objective:To exp lore the relationship between the distribution of Chinese medicine constitution in patients with non-alcoholic fatty pancreas disease(NAFPD)and the factors of incidence-associated glucolipid metabolism.Methods:Judged Chinese medicine constitution of 1604 cases of Ningbo region(946 cases with NAFPD and 658 cases with healthy peop le),and analyzed the relevance of incidence-associated glucolipid metabolism factors with disease susceptible constitution and susceptible constitution respectively by Logistic regression analysis method.Results:In these patients with NAFPD,the distributions of phlegm-dampness constitution,blood stasis constitution and qideficiency constitution were comparativelymore( P <0.05),allbeing factors of disease susceptible constitutions for NAFPD( P <0.05),while the distribution of gentleness constitution was comparatively less( P <0.05).There was a positive correlation in phlegm-dampness constitution and body m ass indexes of NAFPD,accompanied type 2 diabetes mellitus and levels of glycosylated hemoglobin.Blood stasis constitution was positively correlated with aggravated NAFPD and accompanied non-alcoholic fatty liver and was negatively correlated with adiponectin levels,while the qideficiency constitution was disassociated with the related factors above.Conclusion:Phlegm-dampness constitution,blood stasis constitution and qideficiency constitution are the high-frequency constitutions and disease susceptible constitution factors in patients with NAFPD,among which the phlegm-dampness constitution is related to obesity and glucose metabolism disorders and the blood stasis constitution is related to lipid metabolism disorders and the aggravation of visceral lipid deposition.