Objective： To discuss the clinical effect of modified Chaishao Liujun tang for reflux esophagitis of liverdepression and spleen-deficiency type.Methods：Selected 90 cases of patients with reflux esophagitis of liver-depression and spleen-deficiency type，and divided theminto the control group and the observation group randomly，45 cases in each group.The control group was given pantoprazole enteric-coated capsules，while the observation group was given modified Chaishao Liujun tang.After 8 weeks of treatment， compared the clinical effect， Chinese medicine syndrome scores and changes of lesion degree in esophagealmucosa of both groups.Results：After treatment，the total effective rate was 95.56% in the observation group and 77.78%in the control group，difference being significant( P ＜0.05).After treatment，Chinese medicine syndrome scores and the lesion degree in esophagealmucosa in both groups were lower than those before treatment( P ＜0.05)，and Chinese medicine syndrome scores and the lesion degree in esophagealmucosa in the observation group were decreased more significantly than those in the controlgroup( P ＜0.05).Conclusion：Modified Chaishao Liujun tang for reflux esophagitis of liver-depression and spleen-deficiency type has significant therapeutic effect in relieving the clinical symptoms and improving the lesion degree in esophagealmucosa of patients.