Objective：To observe the clinical effect of Xiaoke Bitong capsules com bined with routine therapy for diabetic peripheralneuropathy(DPN)with qideficiency and blood stasis syndrome.Methods：Divided 123 cases of DPN patients with qideficiency and blood stasis syndrome into the treatment group and the control group randomly.The two groups received basic treatment.The treatment group additionally received Xiaoke Bitong capsules for treatment，while the control group additionally received mecobalamin tablets.The two groups received treatment for 12 weeks continuously.Observed the changes of the clinical symptoms and detected the motor nerve conduction velocity(MCV)and sensory nerve conduction velocity(SCV)， and levels of endothelin(ET)and nitric oxide(NO)of patients before and after treatment.Results： After treatment，the total effective rate was 78.33%in the treatment group and was 52.46%in the control group，the difference being significant( P ＜0.05).MCV and SCV in the two groups were improved when compared with those before treatment( P ＜0.05)，and MCV and SCV in the treatment group were improved when compare with those in the controlgroup( P ＜0.05).NO levels in the two groups were increased when compared with those before treatment，while ET levels were decreased when compared with those before treatment，differences being significant( P ＜0.05).NO level in the treatment group was higher than that in the controlgroup，while ET levelwas lower than that in the controlgroup，differences being significant( P ＜0.05).Conclusion：Based on the routine therapy，the additional app lication of Xiaoke Bitong capsules can effectively relieve the clinical symptoms of acral pain，num bness and hypodynamia of DPN patients with qideficiency and blood stasis syndrome，and obviously improve the nerve conduction velocity，which probably plays a therapeutic role by improving the vascular endothelial function.