利妥昔单抗联合真武汤治疗狼疮性肾炎临床观察
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R593.24+2

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Clinical Observation on Rituximab Com bined with Zhenwu Tang for Lupus Nephritis
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    摘要:

    目的:观察利妥昔单抗联合真武汤治疗狼疮性肾炎的临床疗效。方法:将51例狼疮性肾炎患者随机分为对照组25例和观察组26例。对照组给予利妥昔单抗注射液治疗,观察组在利妥昔单抗注射液治疗基础上联合真武汤。比较2组用药前后相关指标的变化,对比分析治疗效果。结果:治疗后,2组血肌酐(SCr)及尿蛋白定量水平均较治疗前降低( P <0.05),血红蛋白(Hb)及血清白蛋白水平均较治疗前升高( P <0.05);观察组SCr及尿蛋白定量水平低于对照组( P <0.05),Hb及血清白蛋白水平均高于对照组( P <0.05)。治疗后,2组C3及C4补体含量均较治疗前提升( P <0.05),观察组C3及C4补体含量多于对照组( P <0.05)。治疗后,2组红细胞沉降率(ESR)、C-反应蛋白(CRP) 水平均较治疗前降低( P <0.05);观察组ESR、CRP水平均低于对照组( P <0.05)。治疗后,观察组抗dsDNA抗体阳性率及总有效率均低于对照组( P <0.05)。结论:利妥昔单抗联合真武汤治疗狼疮性肾炎,可改善患者的肾功能及免疫学相关指标,减轻炎症反应,治疗效果优于单独使用利妥昔单抗。

    Abstract:

    Objective:To observe the clinicaleffect of rituxim ab com bined with Zhenw u tang for lupus nephritis.Methods:Divided 51 cases of patients with lupus nephritis into the controlgroup and the observation group randomly,25 cases and 26 cases respectively in each group.The controlgroup was treated with simple rituxim ab injection while the treatment group was additionally given Zhenw u tang based on the treatment of the control group.Compared the changes in the relevant indicators before and aftermedication in the two groups,and compared and analyzed the therapeutic effects.Results:After treatment,levels of the serum creatinine(SCr)and urine protein quantitation in the two groups were decreased when compared with those before treatment( P <0.05);levels of hemoglobin(Hb)and serum albumin were increased when compared with those before treatment( P <0.05).Levels of the SCr and urine protein quantitation in the observation group were lower than those in the control group( P <0.05);levels of hemoglobin(Hb)and serum albumin were higher than those in the control group( P <0.05).After treatment,contents of C3 and C4 in the two groups were increased when compared with those before treatment( P <0.05).Contents of C3 and C4 in the observation group were higher than those in the control group( P <0.05).After treatment,levels of the erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)were decreased when compared with those before treatment( P <0.05).Levels of the ESR and CRP in the observation groupwere lower than those in the control group( P <0.05).After treatment,the positive rate and total effective rate of anti-dsDNA antibody in the observation group were lower than those in the controlgroup( P <0.05).Conclusion:The therapy of rituxim ab com bined with Zhenw u tang for lupus nephritis can improve the kidney function and relevant immunological indicators of patients and reduce the inflamm atory responses,whose therapeutic effect is better than that of simple administration of rituxim ab.

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刘飞,张红霞,席春生,王谨涵.利妥昔单抗联合真武汤治疗狼疮性肾炎临床观察[J].新中医,2018,50(9):92-94

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  • 在线发布日期: 2018-09-04
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