Objective：To observe the clinical effect of BushenYiqiTongluoHuazhuo prescription for diabetic nephropathy at early stage.Methods：Divided 120 cases of patients with diabetic nephropathy at early stage into the control group and thetreatment group randomly，60 cases in each group.The controlgroup received routine westernmedicine for treatment，while the treatment group was additionally given BushenYiqiTongluoHuazhuo prescription based on the treatment of the control group.The two groups received treatment for one year.Compared the clinicaleffect，scores of Chinese medicine syndromes，fasting blood glucose(FBG)，triglyceride(TG)，total cholesterol(TC)，low density lipoprotein cholesterol(LDL-C)，high density lipoprotein cholesterol(HDL-C)，24h urine protein excretion，urinary microalbumin，urinary albumin excretion rate(UAER)，serum creatinine(SCr)，blood urea nitrogen(BUN)，interleukins-6(IL-6)，IL-1β ，high-sensitivity C-reactive protein(hs-CRP)before and after treatment and the incidence of endpoint events in the two groups.Results： After treatment， the total effective rate was 65.0%in the control group and 90.0%in the treatment group，the difference being significant( P ＜0.05).After treatment，levels of FBG，TC，TG，LDL-C，24h urine protein excretion，urinary microalbumin，BUN，SCr，UAER，IL-6，IL-1β and hs-CRP in the two groups were decreased when compared with those before treatment( P ＜0.05)，and the decrease of the above indexes in the treatment group were more obvious than those in the control group( P ＜0.05).Levels of HDL-C in the two groups were increased when compared with those before treatment( P ＜0.05)，and the increase in the treatment group was more obvious than that in the controlgroup( P ＜0.05).After treatment，the incidence of endpoint events was 63.3%in the controlgroup and 18.3%in the treatment group，the difference being significant( P ＜0.05).Conclusion：The therapy of BushenYiqiTongluoHuazhuo prescription for diabetic nephropathy at early stage can reduce the levels of blood glucose and blood lipid，decrease proteinuria，improve the kidney function and delay the development of disease.