补肾汤联合阿仑膦酸钠治疗肾虚型原发性骨质疏松症临床观察
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Clinical Observation on Bushen Tang Com bined with Alend ronate Sod ium Tablets for Prim ary Osteopo rosis with Kidney Deficiency Type
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    摘要:

    目的:观察肾虚型原发性骨质疏松症应用补肾汤联合阿仑膦酸钠的疗效和不良反应。方法:选取156例肾虚型原发性骨质疏松症患者为研究对象,随机分为治疗组和对照组各88例。对照组应用抗骨质疏松的西药阿仑膦酸钠片治疗,治疗组在对照组的基础上加中药补肾汤治疗。比较2组视觉模拟评分(VAS)、骨密度、临床疗效等。结果:治疗组的总有效率为76.2%,对照组为69.3%,2组间比较,差异有统计学意义( P <0.05)。治疗后,2组VAS评分均显著降低( P <0.01),且治疗组的VAS评分低于对照组( P <0.05)。治疗后,2组各部位骨密度均显著提高( P <0.01),且治疗组骨密度高于对照组( P <0.05)。治疗后,2组血清中骨质的相关指标钙、磷,以及肝、肾功能的变化比较,差异无统计学意义( P >0.05)。结论:补肾汤配合阿仑膦酸钠治疗原发性骨质疏松症比单独应用阿仑膦酸钠能更好地改善患者的临床症状、体征,提高患者骨密度,值得临床推广。

    Abstract:

    Objective:To observe the curative effect and the adverse reactions of Bushen tang com bined with alendronate sodium tablets for prim ary osteoporosis with kidney deficiency type.Methods:Selected 156 cases of patients with prim ary osteoporosis with kidney deficiency type as study objects and divided theminto the treatment group and the control group randomly,88 cases in each group.The control group received anti-osteoporosis western medicine of alendronate sodium tablets for treatment,while the treatment group additionally received Chinese medicine of Bushen tang based on the treatment of the control group.Compared the scores of visual analogue scale(VAS),bone mineral density and the clinical effect in the two groups.Results:The total effective rate was 76.2%in the treatment group and was 69.3%in the control group,the difference being significant( P <0.05).After treatment,VAS scores in the two groups were significantly decreased when compared with those before treatment( P <0.01),and the VAS score in the treatment group was lower than that in the control group( P <0.05).After treatment,bone mineral density in each part in the two groups was significantly improved when compared with that before treatment( P <0.01),and bone mineral density in the treatment group was larger than that in the controlgroup( P <0.05).After treatment,compared with the changes of relevant indexes of bone in serum as calcium and phosphorus and the changes of liver and kidney functions,there was no significance in the difference( P >0.05).Conclusion:The therapy of Bushen tang com bined with alendronate sodium tablets for prim ary osteoporosis with kidney deficiency type is superior to that of simple alendronate sodium tablets.It can better improve the clinical symptoms and body signs,increase bone mineraldensity of patients,which is worthy of promotion and application in clinicalpractice.

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黄永青,邵敏,徐绍俊,姜涛,陈庆真,汪钦生.补肾汤联合阿仑膦酸钠治疗肾虚型原发性骨质疏松症临床观察[J].新中医,2018,50(9):102-105

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  • 在线发布日期: 2018-09-04
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