Objective： To discuss the effects of modified Pingji tang com bined with tamoxifen for patients with hysteromyom a complicated with hyperp lasia of m amm ary glands on the clinical effect，degree of tumor reduction and sex hormone levels.Methods：Selected 200 cases of patients with hysteromyom a complicated with hyperp lasia of m amm ary glands and divided theminto the observation group and the control group randomly according to random num ber table，100 cases in each group.The control group was given tamoxifen，while the observation group was additionally given modified Pingji tang.Observe and compare the changes of uterus，reduction degree of tumor body and sex hormone levels[follicle stimulating hormone(FSH)， luteinizing hormone(LH)， and estradiol(E 2 )]before and after treatment in the two groups.Results：The total effective rate was 96.00%in the observation group and 83.00%in the control group，difference being significant( P ＜0.05).Before treatment，there were no significant difference being found in the volume of uterus and fibroid and levels of FSH，LH and E 2 in the two groups(P＞ 0.05).Compared with those before treatment，the volume of uterus and fibroid in the two groups after treatment was significantly reduced，while the levels of FSH and LH were increased clearly and the level of E 2 was decreased evidently，differences being significant( P ＜0.05).The volume of uterus and fibroid in the observation group was significantly sm aller than that in the control group，while the levels of FSH and LH were m arkedly higher than those in the controlgroup and the E 2 levelwas significantly lower than that in the controlgroup，differences being significant( P ＜0.05).Conclusion：The therapy of modified Pingji tang com bined with tamoxifen for hysteromyom a complicated with hyperplasia of m amm ary glands has an obvious curative effect.It can effectively reduce the volume of the uterus and fibroid，improve the sex hormone levels and has a high value of promotion.