Objective：To observe the curative effect of Baogong Zhixue granules com bined with sex hormone therapy for dysfunctional uterine bleeding in perimenopause with yin-deficiency and blood-heat syndrome.Methods：Divided 110 cases of patients with dysfunctionaluterine bleeding in perimenopause with yin-deficiency and blood-heat syndrome into the control group and the treatment group randomly，55 cases in each group.On the fifth day ofmenstrual cycle orwithin one w eek after diagnostic curettage，the controlgroup received estradiol valerate tablets and dydrogesterone tablets for treatment，while the treatment group additionally received Baogong Zhixue granules in the same period based on the treatment of the controlgroup.The course of treatment for both groups lasted for three menstrual cycles，and the follow-up lasted for three menstrual cycles after treatment.Recorded the hemostatic time，detected levels of hemoglobin，follicle-stimulating hormone(FSH)，luteinizing hormone(LH)，estrogen(E 2 )and progesterone(P)before and after treatment，evaluated the scores of yin-deficiency and blood-heat syndrome，and recorded recurrent cases and calculated the recurrence rate during the three-month follow-up after treatment.Results：After treatment，the rem arkably effective rate of the clinical effect was 83.64%in the treatment group，being higher than that of 65.45%in the control group，the difference being significant( P ＜0.05).The total effective rate of the hemostatic effectwas 92.73%in the treatment group，being higher than that of 76.36%in the control group，the difference being significant( P ＜0.05).The levels of FSH，LH，E 2 and P in serumin the two groups were all decreased when compared with those before treatment( P ＜0.01)，and each index of sex hormone in the treatment group was lower than thatin the controlgroup( P ＜0.01).The levels of hemoglobin in the two groups were increased when compared with those before treatment，and the scores of yin-deficiency and blood-heat syndrome were decreased when compared with before treatment，differences being significant( P ＜0.01).The level of hemoglobin in the treatment group was higher than that in the control group， and the score of yin-deficiency and blood-heat syndrome was lower than that in the control group，differences being significant( P ＜0.01).The recurrence rate was 15.22%in the treatment group，being lower than that of 50.00% in the control group( P ＜0.01).Conclusion：The therapy of Baogong Zhixue granules com bined with sex hormone therapy for patients with dysfunctional uterine bleeding in perimenopause with yin-deficiency and blood-heat syndrome can have the quick hemostatic effect in the short term，effectively improve clinical symptoms，regulate the level of sex hormone，improve the clinicaleffect and reduce the recurrence rate in the long term.