Objective： To study the types of Chinese medicine constitution of patients with multi-drug resistant tuberculosis，discuss the relationship between constitutional factors and the onset of disease，and provide the correspondent theoretical basis for preventive treatment of disease in Chinese medicine.Methods：Selected 201 cases of patients with multi-drug resistant tuberculosis，145 cases form ale and 56 cases for fem ale at the age of 18 to 79.Constitution in Chinese medicine questionnaire was adopted to classify the Chinese medicine constitution，and further discussed the relationship between constitutional factors and the onset ofmulti-drug resistant tuberculosis.Results：Among the 201 cases of patients with multi-drug resistant tuberculosis，there were 3 cases of balanced constitution(1.5%)and 198 cases of unbalanced constitution(98.5%)，among which there were 66 cases of qi-deficiency constitution(32.8%)， 43 cases of qi-depressionconstitution(21.4%)，31 cases of phlegm-dampness constitution(15.4%)and 21 cases of yang-deficiency constitution(10.4%).Regarding the Chinese medicine constitution type scores，the most relevant constitution types are qi-deficiency constitution，qi-depression constitution，phlegm-dampness constitution and yang-deficiency constitution in sequence.Conclusion：The constitution types of patients with multi-drug resistant tuberculosis are m ainly qi-deficiency constitution，qi-depression constitution，phlegm-dampness constitution and yang-deficiency constitution.It is of great significance for directing the individualized treatment formulti-drug resistant tuberculosis and preventing the occurrence of drug-resistance.