Objective：To observe the curative effect of Bushen Huoxue prescription for vertebral compression fracture of senile osteoporosis in perioperative period.Methods：Divided 90 cases of patients into two groups randomly，45 cases in each group.The control group adopted percutaneous kyphoplasty(PKP)for treatment，while the treatment group was additionally given Bushen Huoxue prescription before and after the operation for one w eek respectively based on the treatment of the controlgroup.Observed the scores of the visualanalogue scale(VAS)of pain and the scores of the Oswestry disability index(ODI)at the first，second and fourth weeks before and after the operation.Results：At the first，second and fourthweeks after the operation，VAS scores in the two groups were decreased when compared with those before treatment( P ＜0.05)； at the second and fourth weeks after the operation， VAS score in the treatment group was decreased more significantly than that in the controlgroup( P ＜0.05).At the first，second and fourth weeks after the operation，ODIscores in the two groups were decreased when compared with those before treatment( P ＜0.05)；at the second and fourth weeks after the operation，ODIscore in the treatment group was decreased more significantly than that in the controlgroup( P ＜0.05).Conclusion：Bushen Huoxue prescription can alleviate postoperative pain of patients with vertebral compression fracture of senile osteoporosis after PKP and improve the spine function of patients.