清肺解毒汤对儿童大叶性肺炎免疫凝血状态的影响
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R725.6

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国家中医临床研究基地业务建设科研专项课题(JDZX2012105)


Qing fei Jiedu Tang Has Effect on Immune and Coagu lation State in Child ren with Lobar Pneumonia
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    摘要:

    目的:观察清肺解毒汤对儿童大叶性肺炎免疫、凝血状态的影响,为其临床推广应用提供一定的研究基础。方法:将90例确诊为大叶性肺炎的患儿随机分为治疗组60例,对照组30例。对照组给予常规基础治疗,治疗组予基础治疗联合清肺解毒汤治疗。治疗2个疗程后观察2组治疗前后免疫、凝血指标变化,比较2种治疗方法的安全性。结果:与治疗前比较,2组CD3 + 、CD4 + 、CD4 + /CD8 + 、免疫球蛋白A(IgA)、免疫球蛋白G(IgG) 均显著升高;治疗组血小板计数(BPC)、纤维蛋白原(Fib)、D-二聚体(D-D)含量显著下降,凝血酶时间(TT)、活化部分凝血酶时间(APTT) 含量显著升高;对照组CD8 + 显著升高,凝血酶原时间(PT) 含量显著下降,差异均有统计学意义( P <0.05)。与对照组治疗后比较,治疗组CD3 + 、CD4 + 、CD4 + /CD8 + 、IgA、PT、TT含量显著升高,Fib、D-D含量显著下降,差异均有统计学意义( P <0.05)。治疗组不良反应发生率为1.7%,显著低于对照组23.3%,差异有统计学意义( P <0.05)。结论:清肺解毒汤能明显改善患儿免疫、凝血状态,对预防并发症、改善预后有积极意义,同时安全可靠,值得临床推广和使用。

    Abstract:

    Objective:To observe the effect of Qingfei Jiedu tang on immune and coagulation state in children with lobar pneumonia,and provide research basis for its promotion and application in clinical practice.Methods:Divided 90 cases of children with lobar pneumonia into the treatment group and the control group,60 cases and 30 cases in each group respectively.The control group received routine basic treatment,while the treatment group received basic treatment com bined with Qingfei Jiedu tang.After treatment of two courses,observed the changes of indexes of immunity and coagulation before and after treatment in the two groups,and compared the safety of the two treatments.Results:Contents of CD3 + , CD4 + , CD4 + /CD8 + , immunoglobulin A(IgA)and immunoglobulin G(IgG)in the two groups were significantly increased when compared with those before treatment.Blood p latelet count(BPC),fibrinogen(Fib)and D-dimer(D-D)in the treatment group were significantly decreased when compared with those before treatment,while contents of throm bin time(TT)and activated partial throm boplastin time(APTT)were significantly increased.Content of CD8 + in the control group was significantly increased when compared with that before treatment,while the content of prothrom bin time(PT)was significantly decreased,differences being significant( P <0.05).After treatment,contents of CD3 + ,CD4 + ,CD4 + /CD8 + ,IgA,PT and TT were significantly increased when compared with those in the control group,while the contents of Fib and D-D were significantly decreased,differences being significant( P <0.05).The incidence of adverse reactions was 1.7%in the treatment group and was 23.3%in the control group,difference being significant( P <0.05).Conclusion:The therapy of Qingfei Jiedu tang can obviously improve immune and coagulation state of children,and has a positive significance in improving prognosis with high safety,which is worthy of promotion and application in clinicalpractice.

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管志伟,宋桂华,张岩,吕伟刚,于素平,张炜,王雪峰.清肺解毒汤对儿童大叶性肺炎免疫凝血状态的影响[J].新中医,2018,50(9):127-130

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  • 在线发布日期: 2018-09-04
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