Objective： To observe the clinical effect of Xuanfei Zhike tang for post-infectious cough(PIC).Methods：Divided 108 cases of PIC patients with excessive w ind and spasm syndrome into the controlgroup and the observation group randomly，54 cases in each group.The control group received oral administration ofmontelukast sodium chew able tablets for treatment，while the observation group received Xuanfei Zhike tang.The two groups received treatment for ten days.Evaluated scores of cough symptoms including cough in daytime and nighttime and the scores of visual analogue scale(VAS)，recorded the remission time and disappearance time of cough，and evaluated the quality of life of patients by Leicester Cough Questionnaire(LCQ)before and after treatment.Results：The clinical effect of the observation group was superior to that of the controlgroup( P ＜0.05).The scores of cough in daytime and nighttime and VAS scores in the two groups were decreased when compared with those before treatment( P ＜0.01)；and the above three scores in the observation group were lower than those in the control group( P ＜0.01).The remission time and disappearance time of cough in the observation group were shortened when compared with those in the control group( P ＜0.05).The disappearance rate of cough was 64.81%in the observation group，higher than that of 42.59%in the control group，the difference being significant( P ＜0.05).Scores of physiology，psychology and society in LCQ and the total score were obviously increased when compared with those before treatment( P ＜0.01)；and the scores of the three dimensions and the total score in the observation group were higher than those in the control group( P ＜0.01).Conclusion：The therapy of Xuanfei Zhike tang for PIC with excessive w ind and spasm syndrome can effectively relieve the cough，promote the disappearance of cough，shorten the disease course，improve the quality of life of patients，which has better clinicaleffect than that of simple montelukast sodium chew able tablets.