Objective：To observe the effect of the oral prescription of circum ferentialmixed hemorrhoids com bined with external application of Shengji Yuhong ointment on the promotion of postoperative wound healing of circum ferentialmixed hemorrhoids and the levels of hypoxia-inducible factor(HIF)-1α，vascular endothelial grow th factor(VEGF)and m atrix metalloproteinase(MMP)-9 in serum.Methods：Divided 110 cases of patients with circum ferentialmixed hemorrhoids of w ind-heat stagnation syndrome into the control group and the treatment group randomly，55 cases in each group.Both groups received external dissection and internal ligation for circum ferentialmixed hemorrhoids coordinating with such routine measures as antibiotics against infection and the oraladministration of Qirong Runchang oral liquid，while the treatment group received the external application of Shengji Yuhong ointment after cleaning the wound which was later covered by sterile gauze，and received the decoction of oral prescription of circum ferentialmixed hemorrhoids.The treatment for both groups lasted for 10 days.Compared the recovery conditions(wound pain，wound exudation，wound swelling，granulation tissue in wound and the area of wound)and the clinical effect of the two groups，and detected the levels of HIF-1α ，VEGF and MMP-9 in serumof both groups.Results：On the 10th day after operation，the total effective rate was 94.55%in the treatment group，being significantly higher than 80.00%in the control group，difference being significant( P ＜0.05).The scores of wound pain，exudation，swelling，granulation tissue and its area in both groups were lower than those on the 1st day after operation( P ＜0.01)，and each score in the treatment group was lower than that in the controlgroup respectively( P ＜0.01).The levels of HIF-1α，VEGF and MMP-9 in serumof both groups were lower than those on the 1st day afteroperation( P ＜0.01)，and the levels of the three indexes in the treatment group were lower than those in the control group respectively( P ＜0.01).Conclusion：The oral prescription of circum ferential mixed hemorrhoids com bined with external application of Shengji Yuhong ointment can promote the wound healing of circum ferentialmixed hemorrhoids after external dissection and internal ligation.The dow n-regulation of levels of HIF-1α，VEGF and MMP-9 m ay be relevant with its repairing effect.