环状混合痔内服方联合生肌玉红膏外用促环状混合痔术后创面愈合作用研究
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Oral Prescrip tion of Circum feren tial Mixed Hemo rrhoids Com bined with External App lication of Sheng ji Yuhong Oin tment Has Effect in Promo ting Postoperative Wound Healing of Circum feren tial Mixed Hemo rrhoids
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    摘要:

    目的:观察环状混合痔内服方联合生肌玉红膏外用对环状混合痔术后创面愈合及对血清中缺氧诱导因子(HIF)-1α、血管内皮生长因子(VEGF)和基质金属蛋白酶(MMP)-9水平的影响。方法:将110例环状混合痔风热瘀阻证患者随机分为对照组和治疗组各55例。2组患者均行环状混合痔外剥内扎术,配合抗生素预防感染、服用芪蓉润肠口服液等常规措施,治疗组洗净疮面后以生肌玉红膏外涂,以无菌纱布覆盖,服用环状混合痔内服方水煎液。2组连续治疗10天。比较2组的创面恢复情况(创面疼痛、创面渗出、创面肿胀、创面肉芽组织及创面面积)和临床疗效,检测2组血清中的HIF-1α、VEGF和MMP-9水平。结果:术后10天,治疗组总有效率为94.55%,明显高于对照组的80.00%,差异有统计学意义( P <0.05)。2组创面疼痛、渗出、肿胀、肉芽组织及面积评分均较术后1天减少( P <0.01),治疗组各项评分均低于对照组( P <0.01)。2组血清HIF-1α、VEGF和MMP-9水平均较术后1天降低( P <0.01),治疗组3项指标水平均低于对照组( P <0.01)。结论:环状混合痔内服方联合生肌玉红膏外用可促进环状混合痔外剥内扎术后创面的愈合,下调血清中的HIF-1α、VEGF和MMP-9水平可能与其修复作用有关。

    Abstract:

    Objective:To observe the effect of the oral prescription of circum ferentialmixed hemorrhoids com bined with external application of Shengji Yuhong ointment on the promotion of postoperative wound healing of circum ferentialmixed hemorrhoids and the levels of hypoxia-inducible factor(HIF)-1α,vascular endothelial grow th factor(VEGF)and m atrix metalloproteinase(MMP)-9 in serum.Methods:Divided 110 cases of patients with circum ferentialmixed hemorrhoids of w ind-heat stagnation syndrome into the control group and the treatment group randomly,55 cases in each group.Both groups received external dissection and internal ligation for circum ferentialmixed hemorrhoids coordinating with such routine measures as antibiotics against infection and the oraladministration of Qirong Runchang oral liquid,while the treatment group received the external application of Shengji Yuhong ointment after cleaning the wound which was later covered by sterile gauze,and received the decoction of oral prescription of circum ferentialmixed hemorrhoids.The treatment for both groups lasted for 10 days.Compared the recovery conditions(wound pain,wound exudation,wound swelling,granulation tissue in wound and the area of wound)and the clinical effect of the two groups,and detected the levels of HIF-1α ,VEGF and MMP-9 in serumof both groups.Results:On the 10th day after operation,the total effective rate was 94.55%in the treatment group,being significantly higher than 80.00%in the control group,difference being significant( P <0.05).The scores of wound pain,exudation,swelling,granulation tissue and its area in both groups were lower than those on the 1st day after operation( P <0.01),and each score in the treatment group was lower than that in the controlgroup respectively( P <0.01).The levels of HIF-1α,VEGF and MMP-9 in serumof both groups were lower than those on the 1st day afteroperation( P <0.01),and the levels of the three indexes in the treatment group were lower than those in the control group respectively( P <0.01).Conclusion:The oral prescription of circum ferential mixed hemorrhoids com bined with external application of Shengji Yuhong ointment can promote the wound healing of circum ferentialmixed hemorrhoids after external dissection and internal ligation.The dow n-regulation of levels of HIF-1α,VEGF and MMP-9 m ay be relevant with its repairing effect.

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张玉红,虞哲波.环状混合痔内服方联合生肌玉红膏外用促环状混合痔术后创面愈合作用研究[J].新中医,2018,50(9):161-164

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  • 在线发布日期: 2018-09-04
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